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- W2000349265 abstract "RATIONALE: Very little data is available to determine the threshold dose for egg allergic individuals. Threshold information could be used by the regulatory agencies and food industry to develop guidelines for cross contact testing. METHODS: Children, ages 1-13 yrs, diagnosed with egg allergy by either a serum CAP-FEIA to egg protein >2 kU/L or positive egg challenge within 6 months have undergone an oral desensitization procedure to determine if oral desensitization is a treatment option. The desensitization procedure begins with 0.1 mg of egg protein, increasing the dose until 50 mg of egg protein is tolerated. The cumulative dose associated with the first objective symptoms of an allergic reaction is reported. RESULTS: Thirteen subjects have been enrolled to date. One child reacted after a cumulative dose of 3 mg; another reacted after ingesting 6 mg. Two children reacted after ingesting 12 mg; 3 children reacted after 24 mg. One child reacted after ingesting 87 mg, 4 children reacted after 99 mg, and 1child reacted after 137 mg. The allergic symptoms involved the skin, respiratory and gastrointestinal systems. The CAP-FEIA values ranged from 0.67 to 71.2 kU/L. The children with the highest CAP-FEIA did not coincide with the children who reacted at the lowest dose of egg protein. CONCLUSION: These results have important implications in the establishment of threshold levels for egg protein cross contact. This data demonstrates that the specific serum IgE levels cannot predict clinical reactivity associated with threshold dosing." @default.
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- W2000349265 date "2005-02-01" @default.
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- W2000349265 title "Threshold dose for egg allergy during egg desensitization procedure" @default.
- W2000349265 doi "https://doi.org/10.1016/j.jaci.2004.12.682" @default.
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