FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000351134> ?p ?o ?g. }

• W2000351134 endingPage "71" @default.
• W2000351134 startingPage "67" @default.
• W2000351134 abstract "In an attempt to monitor the pharmacodynamics of mycophenolate mofetil (MMF) we investigated the association of inosine monophosphate dehydrogenase (IMPDH) activity in peripheral blood mononuclear cells with the expression of lymphocyte activation markers in stable cardiac transplant recipients treated with MMF.Twenty-four study patients were switched from azathioprine to MMF 7.2+/-4.1 years after heart transplantation.While the MPA trough level remained unchanged, the mean activity of IMPDH declined from 890 to 462 pmol/10(6)PBMC/h three months after onset of MMF therapy, was almost completely inhibited at six months and partially restored to 160 pmol/10(6)PBMC/h 12 months after switch to MMF (p< .0001). We detected also significant changes in a number of activated lymphocyte subsets: CD4+/25+, CD8+/38+, CD19+/69+, CD3+/16+/56+, natural killer (NK) cells, and monocytes. Moreover, the IMPDH activity profile correlated positively with the number of CD8+/38+ T cells (correlation coefficient (CC) +0.53), and inversely with NK cells (CC -0.52) and CD19+/69+ cells (CC -0.61).We revealed a close association of IMPDH baseline activity in mononuclear cells with the expression of lymphocyte activation markers in stable heart transplant patients after introduction of MMF therapy. This supports the assumption of a rather immunomodulatory than immunosuppressive effect of MMF." @default.
• W2000351134 created "2016-06-24" @default.
• W2000351134 creator A5023149183 @default.
• W2000351134 creator A5036557921 @default.
• W2000351134 creator A5039364058 @default.
• W2000351134 creator A5045314207 @default.
• W2000351134 creator A5078810660 @default.
• W2000351134 creator A5078851229 @default.
• W2000351134 creator A5090820164 @default.
• W2000351134 date "2008-08-01" @default.
• W2000351134 modified "2023-09-23" @default.
• W2000351134 title "Lymphocyte activation and correlation with IMPDH activity under therapy with mycophenolate mofetil" @default.
• W2000351134 cites W1975515009 @default.
• W2000351134 cites W1989997989 @default.
• W2000351134 cites W1990625997 @default.
• W2000351134 cites W1998962849 @default.
• W2000351134 cites W2002726823 @default.
• W2000351134 cites W2005229698 @default.
• W2000351134 cites W2011153296 @default.
• W2000351134 cites W2020131073 @default.
• W2000351134 cites W2040790884 @default.
• W2000351134 cites W2049945208 @default.
• W2000351134 cites W2052161247 @default.
• W2000351134 cites W2052857133 @default.
• W2000351134 cites W2060932201 @default.
• W2000351134 cites W2061904336 @default.
• W2000351134 cites W2062251763 @default.
• W2000351134 cites W2068150247 @default.
• W2000351134 cites W2079560009 @default.
• W2000351134 cites W2081039066 @default.
• W2000351134 cites W2097811455 @default.
• W2000351134 cites W2118463883 @default.
• W2000351134 cites W2132458459 @default.
• W2000351134 cites W2154121987 @default.
• W2000351134 cites W2159296257 @default.
• W2000351134 cites W2164317901 @default.
• W2000351134 cites W2343120559 @default.
• W2000351134 doi "https://doi.org/10.1016/j.cca.2008.04.006" @default.
• W2000351134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18474232" @default.
• W2000351134 hasPublicationYear "2008" @default.
• W2000351134 type Work @default.
• W2000351134 sameAs 2000351134 @default.
• W2000351134 citedByCount "15" @default.
• W2000351134 countsByYear W20003511342012 @default.
• W2000351134 countsByYear W20003511342013 @default.
• W2000351134 countsByYear W20003511342014 @default.
• W2000351134 countsByYear W20003511342016 @default.
• W2000351134 countsByYear W20003511342018 @default.
• W2000351134 countsByYear W20003511342022 @default.
• W2000351134 crossrefType "journal-article" @default.
• W2000351134 hasAuthorship W2000351134A5023149183 @default.
• W2000351134 hasAuthorship W2000351134A5036557921 @default.
• W2000351134 hasAuthorship W2000351134A5039364058 @default.
• W2000351134 hasAuthorship W2000351134A5045314207 @default.
• W2000351134 hasAuthorship W2000351134A5078810660 @default.
• W2000351134 hasAuthorship W2000351134A5078851229 @default.
• W2000351134 hasAuthorship W2000351134A5090820164 @default.
• W2000351134 hasConcept C126322002 @default.
• W2000351134 hasConcept C137061746 @default.
• W2000351134 hasConcept C167672396 @default.
• W2000351134 hasConcept C185592680 @default.
• W2000351134 hasConcept C202751555 @default.
• W2000351134 hasConcept C203014093 @default.
• W2000351134 hasConcept C2776760755 @default.
• W2000351134 hasConcept C2777761686 @default.
• W2000351134 hasConcept C2778033501 @default.
• W2000351134 hasConcept C2778849806 @default.
• W2000351134 hasConcept C2778957590 @default.
• W2000351134 hasConcept C2779134260 @default.
• W2000351134 hasConcept C2909935303 @default.
• W2000351134 hasConcept C2911091166 @default.
• W2000351134 hasConcept C38596361 @default.
• W2000351134 hasConcept C55493867 @default.
• W2000351134 hasConcept C71924100 @default.
• W2000351134 hasConcept C8891405 @default.
• W2000351134 hasConcept C98274493 @default.
• W2000351134 hasConceptScore W2000351134C126322002 @default.
• W2000351134 hasConceptScore W2000351134C137061746 @default.
• W2000351134 hasConceptScore W2000351134C167672396 @default.
• W2000351134 hasConceptScore W2000351134C185592680 @default.
• W2000351134 hasConceptScore W2000351134C202751555 @default.
• W2000351134 hasConceptScore W2000351134C203014093 @default.
• W2000351134 hasConceptScore W2000351134C2776760755 @default.
• W2000351134 hasConceptScore W2000351134C2777761686 @default.
• W2000351134 hasConceptScore W2000351134C2778033501 @default.
• W2000351134 hasConceptScore W2000351134C2778849806 @default.
• W2000351134 hasConceptScore W2000351134C2778957590 @default.
• W2000351134 hasConceptScore W2000351134C2779134260 @default.
• W2000351134 hasConceptScore W2000351134C2909935303 @default.
• W2000351134 hasConceptScore W2000351134C2911091166 @default.
• W2000351134 hasConceptScore W2000351134C38596361 @default.
• W2000351134 hasConceptScore W2000351134C55493867 @default.
• W2000351134 hasConceptScore W2000351134C71924100 @default.
• W2000351134 hasConceptScore W2000351134C8891405 @default.
• W2000351134 hasConceptScore W2000351134C98274493 @default.
• W2000351134 hasIssue "1-2" @default.
• W2000351134 hasLocation W20003511341 @default.
• W2000351134 hasLocation W20003511342 @default.

• next