Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000351290> ?p ?o ?g. }
- W2000351290 endingPage "219" @default.
- W2000351290 startingPage "200" @default.
- W2000351290 abstract "The blood-brain barrier (BBB) is formed by the endothelial cells of cerebral microvessels, providing a dynamic interface between the peripheral circulation and the central nervous system. The tight junctions (TJs) between the endothelial cells serve to restrict blood-borne substances from entering the brain. Under ischemic stroke conditions decreased BBB TJ integrity results in increased paracellular permeability, directly contributing to cerebral vasogenic edema, hemorrhagic transformation, and increased mortality. This loss of TJ integrity occurs in a phasic manner, which is contingent on several interdependent mechanisms (ionic dysregulation, inflammation, oxidative and nitrosative stress, enzymatic activity, and angiogenesis). Understanding the inter-relation of these mechanisms is critical for the development of new therapies. This review focuses on those aspects of ischemic stroke impacting BBB TJ integrity and the principle regulatory pathways, respective to the phases of paracellular permeability." @default.
- W2000351290 created "2016-06-24" @default.
- W2000351290 creator A5001953090 @default.
- W2000351290 creator A5084193351 @default.
- W2000351290 date "2008-11-01" @default.
- W2000351290 modified "2023-10-14" @default.
- W2000351290 title "Blood-brain barrier tight junction permeability and ischemic stroke" @default.
- W2000351290 cites W128151115 @default.
- W2000351290 cites W1504998425 @default.
- W2000351290 cites W1514513302 @default.
- W2000351290 cites W1519239048 @default.
- W2000351290 cites W1528782632 @default.
- W2000351290 cites W1533747850 @default.
- W2000351290 cites W1554042779 @default.
- W2000351290 cites W1559124240 @default.
- W2000351290 cites W1564289234 @default.
- W2000351290 cites W1584238603 @default.
- W2000351290 cites W1591740791 @default.
- W2000351290 cites W1598900543 @default.
- W2000351290 cites W1619234695 @default.
- W2000351290 cites W1638810975 @default.
- W2000351290 cites W1667686291 @default.
- W2000351290 cites W168401264 @default.
- W2000351290 cites W1783580437 @default.
- W2000351290 cites W1792395986 @default.
- W2000351290 cites W1837138728 @default.
- W2000351290 cites W1895792354 @default.
- W2000351290 cites W1897118574 @default.
- W2000351290 cites W1912221395 @default.
- W2000351290 cites W1955617899 @default.
- W2000351290 cites W1955736456 @default.
- W2000351290 cites W1957113176 @default.
- W2000351290 cites W1959189009 @default.
- W2000351290 cites W1963804365 @default.
- W2000351290 cites W1964894126 @default.
- W2000351290 cites W1965916195 @default.
- W2000351290 cites W1966708954 @default.
- W2000351290 cites W1967081185 @default.
- W2000351290 cites W1967733983 @default.
- W2000351290 cites W1968133365 @default.
- W2000351290 cites W1968389835 @default.
- W2000351290 cites W1968634197 @default.
- W2000351290 cites W1968719918 @default.
- W2000351290 cites W1969191130 @default.
- W2000351290 cites W1971222830 @default.
- W2000351290 cites W1972875007 @default.
- W2000351290 cites W1974962627 @default.
- W2000351290 cites W1975216289 @default.
- W2000351290 cites W1975941571 @default.
- W2000351290 cites W1979368709 @default.
- W2000351290 cites W1979390430 @default.
- W2000351290 cites W1979996406 @default.
- W2000351290 cites W1980254242 @default.
- W2000351290 cites W1980614440 @default.
- W2000351290 cites W1981086261 @default.
- W2000351290 cites W1981425827 @default.
- W2000351290 cites W1983864809 @default.
- W2000351290 cites W1985015502 @default.
- W2000351290 cites W1985083844 @default.
- W2000351290 cites W1985221375 @default.
- W2000351290 cites W1985517047 @default.
- W2000351290 cites W1986071376 @default.
- W2000351290 cites W1987177757 @default.
- W2000351290 cites W1987897015 @default.
- W2000351290 cites W1988155976 @default.
- W2000351290 cites W1988780041 @default.
- W2000351290 cites W1989255295 @default.
- W2000351290 cites W1989931839 @default.
- W2000351290 cites W1989970911 @default.
- W2000351290 cites W1990065094 @default.
- W2000351290 cites W1992218027 @default.
- W2000351290 cites W1992758695 @default.
- W2000351290 cites W1994757585 @default.
- W2000351290 cites W1995446848 @default.
- W2000351290 cites W1996537616 @default.
- W2000351290 cites W1996603253 @default.
- W2000351290 cites W1996902174 @default.
- W2000351290 cites W1998237791 @default.
- W2000351290 cites W1998557118 @default.
- W2000351290 cites W2000794581 @default.
- W2000351290 cites W2000929237 @default.
- W2000351290 cites W2002113298 @default.
- W2000351290 cites W2004149224 @default.
- W2000351290 cites W2004159587 @default.
- W2000351290 cites W2004514237 @default.
- W2000351290 cites W2005675003 @default.
- W2000351290 cites W2006610133 @default.
- W2000351290 cites W2008518851 @default.
- W2000351290 cites W2009027924 @default.
- W2000351290 cites W2009034887 @default.
- W2000351290 cites W2009368557 @default.
- W2000351290 cites W2009614974 @default.
- W2000351290 cites W2010461736 @default.
- W2000351290 cites W2010462844 @default.
- W2000351290 cites W2010855741 @default.
- W2000351290 cites W2011583083 @default.
- W2000351290 cites W2012103983 @default.
- W2000351290 cites W2013979525 @default.