FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000351401> ?p ?o ?g. }

• W2000351401 endingPage "e88756" @default.
• W2000351401 startingPage "e88756" @default.
• W2000351401 abstract "Background Bacterial superantigens are virulence factors that cause toxic shock syndrome. Here, the genome-wide, temporal response of mice to lethal intranasal staphylococcal enterotoxin B (SEB) challenge was investigated in six tissues. Results The earliest responses and largest number of affected genes occurred in peripheral blood mononuclear cells (PBMC), spleen, and lung tissues with the highest content of both T-cells and monocyte/macrophages, the direct cellular targets of SEB. In contrast, the response of liver, kidney, and heart was delayed and involved fewer genes, but revealed a dominant genetic program that was seen in all 6 tissues. Many of the 85 uniquely annotated transcripts participating in this shared genomic response have not been previously linked to SEB. Nine of the 85 genes were subsequently confirmed by RT-PCR in every tissue/organ at 24 h. These 85 transcripts, up-regulated in all tissues, annotated to the interferon (IFN)/antiviral-response and included genes belonging to the DNA/RNA sensing system, DNA damage repair, the immunoproteasome, and the ER/metabolic stress-response and apoptosis pathways. Overall, this shared program was identified as a type I and II interferon (IFN)-response and the promoters of these genes were highly enriched for IFN regulatory matrices. Several genes whose secreted products induce the IFN pathway were up-regulated at early time points in PBMCs, spleen, and/or lung. Furthermore, IFN regulatory factors including Irf1, Irf7 and Irf8, and Zbp1, a DNA sensor/transcription factor that can directly elicit an IFN innate immune response, participated in this host-wide SEB signature. Conclusion Global gene-expression changes across multiple organs implicated a host-wide IFN-response in SEB-induced death. Therapies aimed at IFN-associated innate immunity may improve outcome in toxic shock syndromes." @default.
• W2000351401 created "2016-06-24" @default.
• W2000351401 creator A5008820702 @default.
• W2000351401 creator A5023243366 @default.
• W2000351401 creator A5030480737 @default.
• W2000351401 creator A5038056313 @default.
• W2000351401 creator A5042413628 @default.
• W2000351401 creator A5080251578 @default.
• W2000351401 creator A5087335018 @default.
• W2000351401 creator A5087708998 @default.
• W2000351401 date "2014-02-13" @default.
• W2000351401 modified "2023-09-27" @default.
• W2000351401 title "Late Multiple Organ Surge in Interferon-Regulated Target Genes Characterizes Staphylococcal Enterotoxin B Lethality" @default.
• W2000351401 cites W1487205233 @default.
• W2000351401 cites W1932473437 @default.
• W2000351401 cites W1941227479 @default.
• W2000351401 cites W1965134361 @default.
• W2000351401 cites W1970763537 @default.
• W2000351401 cites W1970866626 @default.
• W2000351401 cites W1976740713 @default.
• W2000351401 cites W1984110560 @default.
• W2000351401 cites W1985260941 @default.
• W2000351401 cites W1991185062 @default.
• W2000351401 cites W1991219539 @default.
• W2000351401 cites W1993832002 @default.
• W2000351401 cites W1995445481 @default.
• W2000351401 cites W2003134969 @default.
• W2000351401 cites W2003633341 @default.
• W2000351401 cites W2005353940 @default.
• W2000351401 cites W2009127910 @default.
• W2000351401 cites W2009445020 @default.
• W2000351401 cites W2010445535 @default.
• W2000351401 cites W2010498205 @default.
• W2000351401 cites W2012011074 @default.
• W2000351401 cites W2013760221 @default.
• W2000351401 cites W2017896123 @default.
• W2000351401 cites W2020173029 @default.
• W2000351401 cites W2027853473 @default.
• W2000351401 cites W2028792773 @default.
• W2000351401 cites W2029399674 @default.
• W2000351401 cites W2032908627 @default.
• W2000351401 cites W2036402911 @default.
• W2000351401 cites W2043129892 @default.
• W2000351401 cites W2045941058 @default.
• W2000351401 cites W2050944927 @default.
• W2000351401 cites W2057922117 @default.
• W2000351401 cites W2064201471 @default.
• W2000351401 cites W2065022523 @default.
• W2000351401 cites W2066324618 @default.
• W2000351401 cites W2066938403 @default.
• W2000351401 cites W2071267695 @default.
• W2000351401 cites W2071743575 @default.
• W2000351401 cites W2076493816 @default.
• W2000351401 cites W2082827804 @default.
• W2000351401 cites W2084058369 @default.
• W2000351401 cites W2086417745 @default.
• W2000351401 cites W2092427670 @default.
• W2000351401 cites W2094899168 @default.
• W2000351401 cites W2095577757 @default.
• W2000351401 cites W2096529411 @default.
• W2000351401 cites W2101336752 @default.
• W2000351401 cites W2101777037 @default.
• W2000351401 cites W2103336162 @default.
• W2000351401 cites W2105924489 @default.
• W2000351401 cites W2106007373 @default.
• W2000351401 cites W2106129941 @default.
• W2000351401 cites W2108736984 @default.
• W2000351401 cites W2115366652 @default.
• W2000351401 cites W2120837858 @default.
• W2000351401 cites W2122477043 @default.
• W2000351401 cites W2124773838 @default.
• W2000351401 cites W2128707086 @default.
• W2000351401 cites W2130505168 @default.
• W2000351401 cites W2131272563 @default.
• W2000351401 cites W2134219545 @default.
• W2000351401 cites W2134776341 @default.
• W2000351401 cites W2135703665 @default.
• W2000351401 cites W2138107819 @default.
• W2000351401 cites W2138542983 @default.
• W2000351401 cites W2142980500 @default.
• W2000351401 cites W2144685195 @default.
• W2000351401 cites W2149255271 @default.
• W2000351401 cites W2156728606 @default.
• W2000351401 cites W2157157037 @default.
• W2000351401 cites W2157244998 @default.
• W2000351401 cites W2159698564 @default.
• W2000351401 cites W2162697017 @default.
• W2000351401 cites W2163208642 @default.
• W2000351401 cites W2166617377 @default.
• W2000351401 cites W4235029171 @default.
• W2000351401 cites W4297085868 @default.
• W2000351401 doi "https://doi.org/10.1371/journal.pone.0088756" @default.
• W2000351401 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3923834" @default.
• W2000351401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24551153" @default.
• W2000351401 hasPublicationYear "2014" @default.
• W2000351401 type Work @default.
• W2000351401 sameAs 2000351401 @default.
• W2000351401 citedByCount "21" @default.

• next