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- W2000352451 abstract "Letters1 September 1996Aspirin for Asymptomatic Carotid Artery StenosisWarren S. Browner, MD, MPHWarren S. Browner, MD, MPHVeterans Affairs Medical Center, San Francisco, CA 94211Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-5-199609010-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Dr. Cote and colleagues [1] recently reported that aspirin therapy had no effect on the incidence of vascular events or death in asymptomatic patients with carotid narrowing (hazard ratio, 0.90 [95% CI, 0.62 to 1.33]. They interpreted the results of this excellent study as allowing them “to rule out, with 95% confidence, the possibility that aspirin may reduce the risk for the composite outcomes by 40% or more.” However, 95% CIs do not imply that investigators can be 95% confident: They simply indicate the range of results that are consistent with the measured point estimate [2, 3]. ...References1. Cote R, Battista RN, Abrahamowicz M, Langlois Y, Bourque F, Mackey A, et al. Lack of effect of aspirin in asymptomatic patients with carotid bruits and substantial carotid narrowing. Ann Intern Med. 1995; 123:649-55. Google Scholar2. Browner WS, Newman TB. Are all significant P values created equal? The analogy between diagnostic tests and clinical research. JAMA. 1987; 257:2459-63. Google Scholar3. Browner WS, Newman TB. Confidence intervals. Ann Intern Med. 1986; 105:973-4. Google Scholar Author, Article, and Disclosure InformationAffiliations: Veterans Affairs Medical Center, San Francisco, CA 94211 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCarotid Stenosis: Primary Prevention and Medical Treatment 1 September 1996Volume 125, Issue 5Page: 420KeywordsAspirinCarotid arteriesHazard ratioStenosis Issue Published: 1 September 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ..." @default.
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