FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000353024> ?p ?o ?g. }

• W2000353024 endingPage "1447" @default.
• W2000353024 startingPage "1442" @default.
• W2000353024 abstract "In Brief BACKGROUND: Postoperative nausea and vomiting are unpleasant side effects of general anesthesia. Besides known risk factors (female gender, nonsmoker, history, and opioids), a genetic influence of the serotonin receptor system on the development of nausea and vomiting has repeatedly been proposed. In this pilot study, we therefore investigated the genes of the serotonin receptor subunits A and B (HTR3A and HTR3B) for genetic variants. METHODS: We included 95 patients who had suffered from postoperative vomiting (POV) after general anesthesia and 94 control patients. After DNA isolation, the entire HTR3A and HTR3B coding regions, the 5′ flanking regions, and exon/intron boundaries were screened for genetic variants. Correlation of identified genetic variants with POV was determined by logistic regression. RESULTS: We identified 16 different variants in the HTR3A gene and 19 in the HTR3B gene. By using a multivariate logistic regression model that also included classical risk factors, the HTR3A variant c1377A>G was associated with a significantly higher risk (odds ratio [OR] 2.972; 95% confidence interval [CI] 1.466–6.021; P = 0.003) and the HTR3B variants c5+201_+202delCA (OR 0.421; 95% CI 0.257–0.69; P = 0.001) and c6-137C>T (OR 0.034; 95% CI 0.003–0.332; P = 0.004) were associated with a lower risk for POV. However, all significant genetic variants were located in noncoding regions of their gene. CONCLUSIONS: Genetic variations in the HTR3A and HTR3B gene seem to be associated with the individual risk of developing POV. How strong their influence is within the multifactorial genesis of POV needs to be investigated in additional studies with an appropriate sample size. Published ahead of print August 27, 2009" @default.
• W2000353024 created "2016-06-24" @default.
• W2000353024 creator A5010119665 @default.
• W2000353024 creator A5014824637 @default.
• W2000353024 creator A5017496633 @default.
• W2000353024 creator A5027098549 @default.
• W2000353024 creator A5028284175 @default.
• W2000353024 creator A5061396042 @default.
• W2000353024 creator A5062524052 @default.
• W2000353024 creator A5066455966 @default.
• W2000353024 creator A5070754153 @default.
• W2000353024 date "2009-11-01" @default.
• W2000353024 modified "2023-10-15" @default.
• W2000353024 title "Do Variations in the 5-HT3A and 5-HT3B Serotonin Receptor Genes (HTR3A and HTR3B) Influence the Occurrence of Postoperative Vomiting?" @default.
• W2000353024 cites W1506721390 @default.
• W2000353024 cites W178276353 @default.
• W2000353024 cites W1923513268 @default.
• W2000353024 cites W1983072149 @default.
• W2000353024 cites W1997804893 @default.
• W2000353024 cites W1998110762 @default.
• W2000353024 cites W1999179893 @default.
• W2000353024 cites W2012228417 @default.
• W2000353024 cites W2013907105 @default.
• W2000353024 cites W2027206415 @default.
• W2000353024 cites W2031862004 @default.
• W2000353024 cites W2038615689 @default.
• W2000353024 cites W2059915431 @default.
• W2000353024 cites W2062218497 @default.
• W2000353024 cites W2069671955 @default.
• W2000353024 cites W2080017976 @default.
• W2000353024 cites W2088523998 @default.
• W2000353024 cites W2092141642 @default.
• W2000353024 cites W2096091943 @default.
• W2000353024 cites W2127992301 @default.
• W2000353024 cites W2154735290 @default.
• W2000353024 cites W2164907650 @default.
• W2000353024 cites W2218699541 @default.
• W2000353024 cites W2323344932 @default.
• W2000353024 doi "https://doi.org/10.1213/ane.0b013e3181b2359b" @default.
• W2000353024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19713259" @default.
• W2000353024 hasPublicationYear "2009" @default.
• W2000353024 type Work @default.
• W2000353024 sameAs 2000353024 @default.
• W2000353024 citedByCount "53" @default.
• W2000353024 countsByYear W20003530242012 @default.
• W2000353024 countsByYear W20003530242013 @default.
• W2000353024 countsByYear W20003530242014 @default.
• W2000353024 countsByYear W20003530242015 @default.
• W2000353024 countsByYear W20003530242016 @default.
• W2000353024 countsByYear W20003530242017 @default.
• W2000353024 countsByYear W20003530242018 @default.
• W2000353024 countsByYear W20003530242019 @default.
• W2000353024 countsByYear W20003530242020 @default.
• W2000353024 countsByYear W20003530242021 @default.
• W2000353024 countsByYear W20003530242022 @default.
• W2000353024 countsByYear W20003530242023 @default.
• W2000353024 crossrefType "journal-article" @default.
• W2000353024 hasAuthorship W2000353024A5010119665 @default.
• W2000353024 hasAuthorship W2000353024A5014824637 @default.
• W2000353024 hasAuthorship W2000353024A5017496633 @default.
• W2000353024 hasAuthorship W2000353024A5027098549 @default.
• W2000353024 hasAuthorship W2000353024A5028284175 @default.
• W2000353024 hasAuthorship W2000353024A5061396042 @default.
• W2000353024 hasAuthorship W2000353024A5062524052 @default.
• W2000353024 hasAuthorship W2000353024A5066455966 @default.
• W2000353024 hasAuthorship W2000353024A5070754153 @default.
• W2000353024 hasBestOaLocation W20003530241 @default.
• W2000353024 hasConcept C104317684 @default.
• W2000353024 hasConcept C126322002 @default.
• W2000353024 hasConcept C135763542 @default.
• W2000353024 hasConcept C151956035 @default.
• W2000353024 hasConcept C153209595 @default.
• W2000353024 hasConcept C156957248 @default.
• W2000353024 hasConcept C2780580376 @default.
• W2000353024 hasConcept C2780852908 @default.
• W2000353024 hasConcept C44249647 @default.
• W2000353024 hasConcept C54355233 @default.
• W2000353024 hasConcept C60644358 @default.
• W2000353024 hasConcept C71924100 @default.
• W2000353024 hasConcept C86803240 @default.
• W2000353024 hasConcept C90924648 @default.
• W2000353024 hasConceptScore W2000353024C104317684 @default.
• W2000353024 hasConceptScore W2000353024C126322002 @default.
• W2000353024 hasConceptScore W2000353024C135763542 @default.
• W2000353024 hasConceptScore W2000353024C151956035 @default.
• W2000353024 hasConceptScore W2000353024C153209595 @default.
• W2000353024 hasConceptScore W2000353024C156957248 @default.
• W2000353024 hasConceptScore W2000353024C2780580376 @default.
• W2000353024 hasConceptScore W2000353024C2780852908 @default.
• W2000353024 hasConceptScore W2000353024C44249647 @default.
• W2000353024 hasConceptScore W2000353024C54355233 @default.
• W2000353024 hasConceptScore W2000353024C60644358 @default.
• W2000353024 hasConceptScore W2000353024C71924100 @default.
• W2000353024 hasConceptScore W2000353024C86803240 @default.
• W2000353024 hasConceptScore W2000353024C90924648 @default.
• W2000353024 hasIssue "5" @default.
• W2000353024 hasLocation W20003530241 @default.
• W2000353024 hasLocation W20003530242 @default.

• next