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- W2000353620 abstract "The human peripheral-type benzodiazepine receptor (PBR) has been produced in Saccharomyces cerevisiae where it retains its pharmacological properties [Riond et al., Eur. J. Pharmacol. 208 (1991) 307–312]. As the rate of production was low, we analysed the mRNA level, the effect of variation of the 5' sequence and the production in mitochondria. Translation rather than transcription or targeting was found to be the main limiting factor. We were able to produce a chimeric PBR, with an N-terminal extension, to a very high level in the yeast mitochondrial membrane" @default.
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- W2000353620 date "1995-04-01" @default.
- W2000353620 modified "2023-09-29" @default.
- W2000353620 title "High-level production of a human membrane protein in yeast: The peripheral-type benzodiazepine receptor" @default.
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- W2000353620 doi "https://doi.org/10.1016/0378-1119(94)00727-a" @default.
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