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• W2000355290 endingPage "107" @default.
• W2000355290 startingPage "101" @default.
• W2000355290 abstract "The expression of the cytochrome P4501A1 gene, CYP1A1, is induced by e.g. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) mainly by transcriptional mechanisms. The inducers mediate their effect upon binding and activation of the aryl hydrocarbon receptor (AHR) transcription-factor complex. Utilizing chimeric CYP1A1/CAT constructs transient gene expression experiments indicate that the putative negative regulatory element (NRE) of CYP1A1 influence the relative TCDD induced CAT activity in HepG2 cells, whereas this effect was not observed in MCF-7 cells. Differences in the formation of cell-specific protein-DNA complexes were demonstrated by gel retardation assays suggesting a functional difference of NRE in these two cell lines." @default.
• W2000355290 created "2016-06-24" @default.
• W2000355290 creator A5029131616 @default.
• W2000355290 creator A5046011134 @default.
• W2000355290 date "1995-05-29" @default.
• W2000355290 modified "2023-09-25" @default.
• W2000355290 title "Effect of a negative regulatory element (NRE) on the humanCYP1A1gene expression in breast carcinoma MCF-7 and hepatoma HepG2 cells" @default.
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• W2000355290 doi "https://doi.org/10.1016/0014-5793(95)00456-j" @default.
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