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- W2000355924 abstract "The mechanism of the antifungal action of AKD-2C was studied by using Torulaspora delbrueckii IFO 1621 as a model. AKD-2C slightly inhibited the incorporation of radioactive precursors into protein, RNA and lipid, but not into DNA. On the other hand, AKD-2C greatly enhanced the leakage of K+ ions from treated cells and showed a potent effect on liposomal glucose leakage. Using electron microscopic studies, though drastic morphological changes were not observed, an increase in cell membrane irregularities and swelling of the mitochondria caused by AKD-2C were demonstrated. These results suggest that the antifungal action of AKD-2C is due to effects on the yeast cell membrane." @default.
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- W2000355924 date "1998-01-01" @default.
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- W2000355924 title "The Mode of Action of AKD-2C, an Antifungal Antibiotic from Streptomyces sp. OCU-42815." @default.
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- W2000355924 doi "https://doi.org/10.7164/antibiotics.51.852" @default.
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