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• W200035608 abstract "Osszefoglalas: A kutya mint modellallat csak az elmult 15 evben kerult az erdeklődes kozeppontjaba. A kutya retinaja kulonosen erdekes, mivel szamos orokletes retinadegeneracio szoros homologiat mutat az ember hasonlo betegsegeivel. Roviden osszefoglaljuk a kutya retinajanak sajatossagait es azokat az alapkutatasban hasznalt modszereket, melyek segitsegevel a retina degeneracioja leirhato kutyaban. A kutya orokletes retinadegeneracioi kozul a szemeszek szamara a legerdekesebb csoport a progressziv retinalis atrophia (PRA), mivel genetikai, patologiai es klinikai szempontbol is nagyon hasonlo a retinitis pigmentosa kulonboző tipusaihoz. A PRA csoport tagjai elő modellrendszerek, melyek alkalmazhatok az orokletes retinadegeneraciok alapes klinikai kutatasaban egyarant. Ezekben a sulyos es mindenekelőtt gyogyithatatlan betegsegekben uj terapias lehetősegek kidolgozasat segithetik elő. Kulcsszavak: retinadegeneraciok, kutya, progressziv retinalis atrophia, retinitis pigmentosa, kutyaretina Summary: The dog has attracted the attention of basic research as a model animal for hereditary diseases only in the last 15 years. The canine retina is especially interesting, because numerous inherited retinal diseases show a close homology to human diseases. Here, we briefly review the morphology of the canine retina and methods of basic research describing retinal degenerations in the dog. For ophthalmologists, the most relevant inherited retinal disease group in dogs is progressive retinal atrophy (PRA), since it displays high similarity to different types of retinitis pigmentosa in terms of genetic, pathological and clinical features. Diseases of the PRA group serve as good model systems for both basic and clinical research into inherited retinal degenerations. They may lead the way in the development of new therapeutic strategies for the treatment of these severe and, for the most part, incurable retinal disorders." @default.
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• W200035608 date "2011-01-01" @default.
• W200035608 modified "2023-09-27" @default.
• W200035608 title "A Kutya Mint Modell az Örökletes Retinadegenerációk Kutatásában / The Dog as a Model in Research Into Inherited Retinal Degenerations" @default.
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