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- W2000356877 abstract "Abstract The capacity of a thymus-independent antigen, i.e., trinitrophenylated lipopolysaccharide (TNP-LPS), to induce and stimulate memory cells was investigated. C57BL/6 mice were immunized with an optimal immunogenic dose of TNP-LPS and the parameters of the antihapten response obtained from a later challenge with the same antigen were defined, at the antibody-secreting cell level, both in vivo and in vitro . Compared to the primary response, the secondary in vivo anti-TNP response is characterized by a shift in kinetics and the appearance of anti-TNP antibodies of the IgG isotype. The generation, by TNP-LPS, of a TNP-specific B-cell memory as expressed in IgG antibody synthesis does not require the presence of functional T cells; it can be obtained in irradiated hosts reconstituted with spleen cells depleted of Thy-1-positive cells. In vitro , TNP-LPS-primed spleen cells give rise to a T-independent anti-TNP response which is up to 15-fold higher than the primary response. This enhanced anti-hapten IgM response requires cellular division. The priming effect by TNP-LPS is specific for the TNP moiety of the TNP-LPS molecule and persists for at least 11 weeks. These results indicate that, in C57BL/6 mice, stimulation with TNP-LPS leads to the differentiation of B cells not only into antibody-forming cells but also into memory cells which can subsequently be triggered by the same antigen. Both the generation and the activation of TNP-specific B-cell memory by TNP-LPS implicate T-cell-independent events." @default.
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- W2000356877 title "Induction and differentiation of B memory cells by a thymus-independent antigen, trinitrophenylated lipopolysaccharide" @default.
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- W2000356877 doi "https://doi.org/10.1016/0008-8749(81)90091-5" @default.
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