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- W2000356901 abstract "The present study employed differential library screening to identify genes associated with kainic acid (KA)-mediated selective neuronal death. One of the isolated clones was lamp-1, which encodes a major lysosomal membrane protein that is also present in the cell membrane. Following systemic KA treatment, lamp-1 was induced in vulnerable hippocampal and other limbic regions. This effect was blocked by cycloheximide (CHX) pre-treatment. Northern blot analysis also demonstrated the presence of lamp-1 transcripts in non-neural tissues. These findings suggest a novel role for lysosomal membrane proteins as markers of selective neuronal vulnerability. © 1997 Elsevier Science B.V. All rights reserved." @default.
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- W2000356901 date "1997-05-01" @default.
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- W2000356901 title "Isolation of the gene encoding lamp-1, a lysosomal membrane protein, by differential screening in an animal model of status epilepticus" @default.
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- W2000356901 doi "https://doi.org/10.1016/s0169-328x(97)00075-2" @default.
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