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- W2000357892 abstract "In this paper we report clouding phenomenon occurring in an amphiphilic phenothiazine drug promethazine hydrochloride (PMT) in presence of surfactants. Cationic and nonionic surfactants increase the CP of 75 mM PMT solutions (prepared in 10 mM sodium phosphate buffer). These surfactants form mixed micelles with PMT. Anionic surfactants also form mixed micelles with the drug but the CP behavior is different by showing a peaked behavior. At low concentrations, anionic surfactants hinder micelle formation by forming ion-pairs whereas the usual CP decreasing effect at higher concentrations is due to mixed micellization. The CP behavior of 75 mM PMT+50 mM TBAB+surfactant systems is also explored which is found similar to PMT+surfactant systems with the difference only in magnitude of the clouding temperature." @default.
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- W2000357892 date "2011-12-01" @default.
- W2000357892 modified "2023-09-26" @default.
- W2000357892 title "Cloud point variation of amphiphilic drug promethazine hydrochloride with added surfactants" @default.
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- W2000357892 doi "https://doi.org/10.1016/j.colsurfb.2011.07.034" @default.
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