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• W2000358418 abstract "We investigated the possible involvement of mast cells in acute hepatic injury induced by galactosamine (GalN, 20 mg/mouse) and lipopolysaccharide (LPS, 15 ng/mouse) (GalN/LPS) in mice. Histidine decarboxylase (HDC) mRNA expression in the liver as well as serum ALT level was increased with time after GalN/LPS treatment. Steroid anti-inflammatory agent (dexamethasone), histamine H1 receptor antagonists (diphenhydramine and pyrilamine), histamine H2 receptor antagonists (cimetidine and ranitidine) and 5-HT2 receptor antagonist (ketanserin) were effective in reducing the ALT level at 8 h after the treatment with GalN/LPS. Furthermore, dexamethasone, diphenhydramine and cimetidine inhibited the increase in hepatic HDC mRNA level. The increase in ALT level by GalN/LPS was much lower in mast cell-deficient mice than in the congenic normal mice. Diphenhydramine further inhibited ALT level in response to GalN/LPS in mast cell-deficient mice. Our data suggest that mast cells play an important role in the development of hepatic injury induced by GalN/LPS, and suggest that histamine and 5-HT released from mast cells and other cells are involved in this model.(Communicated by Masanori OTSUKA, M. J. A., June 10, 2003)" @default.
• W2000358418 created "2016-06-24" @default.
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• W2000358418 date "2003-01-01" @default.
• W2000358418 modified "2023-09-23" @default.
• W2000358418 title "Involvement of mast cells in acute hepatic injury induced by galactosamine and lipopolysaccharide in mice" @default.
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• W2000358418 doi "https://doi.org/10.2183/pjab.79b.170" @default.
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