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- W2000358664 abstract "A novel tumor necrosis factor-alpha mutant (mutant M3), in which Ser and Tyr at positions 52 and 56 were substituted by Ile and Phe, respectively, along with deletion of 7 N-terminal amino acids, was prepared and its biological activities were investigated. The mutant exhibited a 14- to 24-fold increase in the cytotoxicity relative to the wild-type TNF on various cancer cell lines. The binding affinity of the mutant to TNF-R55 and TNF-R75 receptors was over 10-fold higher than that of the wild-type. TNF-alpha and the mutant show similar CD spectra in the far-UV region, indicating that the overall structure was not influenced by the mutations. The production of highly potent TNF-alpha mutant utilizing increase of hydrophobicity in the region 52-56 may provide a structural basis for a design of optimized TNF-alpha as a therapeutic purpose." @default.
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- W2000358664 date "1998-05-01" @default.
- W2000358664 modified "2023-09-23" @default.
- W2000358664 title "A novel tumor necrosis factor-α mutant with significantly enhanced cytotoxicity and receptor binding affinity" @default.
- W2000358664 doi "https://doi.org/10.1080/15216549800202142" @default.
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