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• W2000359281 abstract "A miniature fiber optic spectrometer enclosed within a semipermeable (dialysis) membrane is proposed for in vivo interstitial sensing applications. The semipermeable membrane acts as a molecular filter, allowing only small molecules to pass through to the sampling volume. This filtering, in principle, should enable continuous in vivo drug sensing, removing the necessity for complex microdialysis systems. We use a biological phantom to examine the reliable detection of a fluorescence signal from small dye molecules in the presence of large fluorophores and scatterers. We find that spectral artefacts arising from scatterers and large fluorophores are substantially suppressed, simplifying the spectral analysis. In addition, the measured sampling rate of 157 s is superior to existing in vivo tissue assaying techniques such as microdialysis, which can take tens of minutes." @default.
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• W2000359281 date "2006-01-01" @default.
• W2000359281 modified "2023-09-24" @default.
• W2000359281 title "Dialysis-assisted fiber optic spectroscopy for in situ biomedical sensing" @default.
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• W2000359281 doi "https://doi.org/10.1117/1.2166086" @default.
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