Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000359348> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2000359348 endingPage "e97621" @default.
- W2000359348 startingPage "e97621" @default.
- W2000359348 abstract "Mycobacterium avium subspecies paratuberculosis (MAP) asymptomatic infection has been previously linked to Type 1 diabetes (T1D) and Multiple Sclerosis. An association between MAP infection and Hashimoto's thyroiditis (HT) was also proposed only in a case report. This study aimed to investigate the robustness of the latter association, testing a large cohort of HT and healthy control (HCs) subjects, all from Sardinia. Prevalence of anti-MAP3865c Abs was assessed by indirect enzyme-linked immunosorbent assay (ELISA). Moreover, given that human ZnT8 is specifically expressed in the pancreatic β-cells, in the follicle epithelial cells and in the parafollicular cells of the thyroid gland, we also tested ZnT8 epitopes homologues to the MAP3865c immunodominant peptides previously identified. Indeed, Abs targeting MAP3865c and ZnT8 homologous regions display similar frequencies in patients and controls, thus suggesting that Abs recognizing these epitopes could be cross-reactive. A statistically significant difference was found between HT patients and HCs when analyzing the humoral response mounted against MAP3865c/ZnT8 homologues epitopes. To our knowledge, this is the first report, which provides statistically significant evidence sustaining the existence of an association between MAP sero-reactivity and HT. Further studies are required to investigate the relevance of MAP to HT, aimed at deciphering if this pathogen can be at play in triggering this autoimmune disease. Likewise, genetic polymorphism of the host, and other environmental factors need to be investigated." @default.
- W2000359348 created "2016-06-24" @default.
- W2000359348 creator A5002538445 @default.
- W2000359348 creator A5035544897 @default.
- W2000359348 creator A5044937917 @default.
- W2000359348 creator A5049327370 @default.
- W2000359348 date "2014-05-15" @default.
- W2000359348 modified "2023-10-01" @default.
- W2000359348 title "Recognition of Zinc Transporter 8 and MAP3865c Homologous Epitopes by Hashimoto's Thyroiditis Subjects from Sardinia: A Common Target with Type 1 Diabetes?" @default.
- W2000359348 cites W1983480534 @default.
- W2000359348 cites W1983542019 @default.
- W2000359348 cites W1987137294 @default.
- W2000359348 cites W1992205458 @default.
- W2000359348 cites W2009812252 @default.
- W2000359348 cites W2049388150 @default.
- W2000359348 cites W2068634263 @default.
- W2000359348 cites W2073625243 @default.
- W2000359348 cites W2075119822 @default.
- W2000359348 cites W2104896157 @default.
- W2000359348 cites W2111356336 @default.
- W2000359348 cites W2142058069 @default.
- W2000359348 cites W2142739531 @default.
- W2000359348 cites W2155021625 @default.
- W2000359348 cites W2164043124 @default.
- W2000359348 cites W2170720263 @default.
- W2000359348 doi "https://doi.org/10.1371/journal.pone.0097621" @default.
- W2000359348 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4022723" @default.
- W2000359348 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24830306" @default.
- W2000359348 hasPublicationYear "2014" @default.
- W2000359348 type Work @default.
- W2000359348 sameAs 2000359348 @default.
- W2000359348 citedByCount "23" @default.
- W2000359348 countsByYear W20003593482014 @default.
- W2000359348 countsByYear W20003593482015 @default.
- W2000359348 countsByYear W20003593482016 @default.
- W2000359348 countsByYear W20003593482017 @default.
- W2000359348 countsByYear W20003593482018 @default.
- W2000359348 countsByYear W20003593482019 @default.
- W2000359348 countsByYear W20003593482021 @default.
- W2000359348 countsByYear W20003593482022 @default.
- W2000359348 crossrefType "journal-article" @default.
- W2000359348 hasAuthorship W2000359348A5002538445 @default.
- W2000359348 hasAuthorship W2000359348A5035544897 @default.
- W2000359348 hasAuthorship W2000359348A5044937917 @default.
- W2000359348 hasAuthorship W2000359348A5049327370 @default.
- W2000359348 hasBestOaLocation W20003593481 @default.
- W2000359348 hasConcept C126322002 @default.
- W2000359348 hasConcept C142724271 @default.
- W2000359348 hasConcept C159654299 @default.
- W2000359348 hasConcept C195616568 @default.
- W2000359348 hasConcept C203014093 @default.
- W2000359348 hasConcept C2777849792 @default.
- W2000359348 hasConcept C2777910003 @default.
- W2000359348 hasConcept C2778696486 @default.
- W2000359348 hasConcept C2779134260 @default.
- W2000359348 hasConcept C2780015948 @default.
- W2000359348 hasConcept C2780130043 @default.
- W2000359348 hasConcept C2780374374 @default.
- W2000359348 hasConcept C2781069245 @default.
- W2000359348 hasConcept C71924100 @default.
- W2000359348 hasConcept C86803240 @default.
- W2000359348 hasConceptScore W2000359348C126322002 @default.
- W2000359348 hasConceptScore W2000359348C142724271 @default.
- W2000359348 hasConceptScore W2000359348C159654299 @default.
- W2000359348 hasConceptScore W2000359348C195616568 @default.
- W2000359348 hasConceptScore W2000359348C203014093 @default.
- W2000359348 hasConceptScore W2000359348C2777849792 @default.
- W2000359348 hasConceptScore W2000359348C2777910003 @default.
- W2000359348 hasConceptScore W2000359348C2778696486 @default.
- W2000359348 hasConceptScore W2000359348C2779134260 @default.
- W2000359348 hasConceptScore W2000359348C2780015948 @default.
- W2000359348 hasConceptScore W2000359348C2780130043 @default.
- W2000359348 hasConceptScore W2000359348C2780374374 @default.
- W2000359348 hasConceptScore W2000359348C2781069245 @default.
- W2000359348 hasConceptScore W2000359348C71924100 @default.
- W2000359348 hasConceptScore W2000359348C86803240 @default.
- W2000359348 hasIssue "5" @default.
- W2000359348 hasLocation W20003593481 @default.
- W2000359348 hasLocation W20003593482 @default.
- W2000359348 hasLocation W20003593483 @default.
- W2000359348 hasLocation W20003593484 @default.
- W2000359348 hasOpenAccess W2000359348 @default.
- W2000359348 hasPrimaryLocation W20003593481 @default.
- W2000359348 hasRelatedWork W1966753344 @default.
- W2000359348 hasRelatedWork W1994399780 @default.
- W2000359348 hasRelatedWork W2010079118 @default.
- W2000359348 hasRelatedWork W2042848281 @default.
- W2000359348 hasRelatedWork W2084801194 @default.
- W2000359348 hasRelatedWork W2115514253 @default.
- W2000359348 hasRelatedWork W2161246929 @default.
- W2000359348 hasRelatedWork W2464068520 @default.
- W2000359348 hasRelatedWork W2477011280 @default.
- W2000359348 hasRelatedWork W3101274966 @default.
- W2000359348 hasVolume "9" @default.
- W2000359348 isParatext "false" @default.
- W2000359348 isRetracted "false" @default.
- W2000359348 magId "2000359348" @default.
- W2000359348 workType "article" @default.