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- W2000359507 abstract "Herpes simplex virus particles were demonstrated by electron microscopy in the corneal stromal cells of a high percentage of rabbits with primary herpetic keratitis. Virus particles were found in the epithelial cells of all infected corneas. Experimental infection was achieved by dropping virus suspension on the cornea without any accompanying artificial trauma. The results demonstrate that the stroma can be infected by virus particles that have entered through the intact epithelium. The findings support the hypothesis that virus particles mature within nuclei and derive their outer coat, or membrane, from the inner leaflet of the nuclear membrane as they pass through it. Virus particles that apparently were phagocytosed by polymorphonuclear leucocytes consisted of a single coat or membrane; they lacked both a central core and an outer coat." @default.
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- W2000359507 date "1968-01-01" @default.
- W2000359507 modified "2023-09-26" @default.
- W2000359507 title "Further investigations by electron microscopy of herpes simplex virus in the corneal stroma of rabbits with experimental keratitis" @default.
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- W2000359507 doi "https://doi.org/10.1016/s0014-4835(68)80037-5" @default.
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