FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000359574> ?p ?o ?g. }

• W2000359574 endingPage "12575" @default.
• W2000359574 startingPage "12570" @default.
• W2000359574 abstract "Although mammalian polypyrimidine tract-binding (PTB) protein functions in most or all cell types to regulate a wide spectrum of transcripts, Drosophila PTB encodes an abundant male germline-specific mRNA isoform (dmPTB) whose expression correlates with male fertility. The biological function of this isoform is unknown. Using selection–amplification, we show that mammalian and Drosophila PTB have similar RNA sequence preference, suggesting that cell-specific expression rather than unique RNA-binding properties account for the sex-specific function of dmPTB. We also show that the dmPTB protein isoform expressed in the male germline is by far the most abundant isoform, and reduction of its levels correlates with male sterility. Finally, we show that dmPTB expression is necessary for proper spermatid individualization, the terminal step necessary for production of motile sperm. Loss of dmPTB results in severe disruption of the actin cones of the spermatid individualization complex. This represents a cytological defect resulting from PTB loss. We discuss the basis for functional differences between mammalian and Drosophila PTB orthologs." @default.
• W2000359574 created "2016-06-24" @default.
• W2000359574 creator A5014910645 @default.
• W2000359574 creator A5041978411 @default.
• W2000359574 creator A5047600326 @default.
• W2000359574 creator A5047609765 @default.
• W2000359574 creator A5076795852 @default.
• W2000359574 date "2010-06-28" @default.
• W2000359574 modified "2023-09-25" @default.
• W2000359574 title "<i>Drosophila</i> polypyrimidine tract-binding protein is necessary for spermatid individualization" @default.
• W2000359574 cites W1910936647 @default.
• W2000359574 cites W1974898488 @default.
• W2000359574 cites W1980331623 @default.
• W2000359574 cites W1987719717 @default.
• W2000359574 cites W1995239307 @default.
• W2000359574 cites W1999297599 @default.
• W2000359574 cites W2003318299 @default.
• W2000359574 cites W2008540641 @default.
• W2000359574 cites W2010442242 @default.
• W2000359574 cites W2024661709 @default.
• W2000359574 cites W2030547825 @default.
• W2000359574 cites W2033593485 @default.
• W2000359574 cites W2043435109 @default.
• W2000359574 cites W2043927796 @default.
• W2000359574 cites W2059293195 @default.
• W2000359574 cites W2079321730 @default.
• W2000359574 cites W2079646415 @default.
• W2000359574 cites W2085420149 @default.
• W2000359574 cites W2089346704 @default.
• W2000359574 cites W2097572021 @default.
• W2000359574 cites W2100524248 @default.
• W2000359574 cites W2110901570 @default.
• W2000359574 cites W2117293520 @default.
• W2000359574 cites W2124144440 @default.
• W2000359574 cites W2146856679 @default.
• W2000359574 cites W2147207574 @default.
• W2000359574 cites W2154565932 @default.
• W2000359574 cites W2155001271 @default.
• W2000359574 cites W2159958242 @default.
• W2000359574 cites W2164043757 @default.
• W2000359574 cites W2189539444 @default.
• W2000359574 doi "https://doi.org/10.1073/pnas.1007935107" @default.
• W2000359574 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2906604" @default.
• W2000359574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20616016" @default.
• W2000359574 hasPublicationYear "2010" @default.
• W2000359574 type Work @default.
• W2000359574 sameAs 2000359574 @default.
• W2000359574 citedByCount "21" @default.
• W2000359574 countsByYear W20003595742012 @default.
• W2000359574 countsByYear W20003595742013 @default.
• W2000359574 countsByYear W20003595742015 @default.
• W2000359574 countsByYear W20003595742016 @default.
• W2000359574 countsByYear W20003595742019 @default.
• W2000359574 countsByYear W20003595742021 @default.
• W2000359574 countsByYear W20003595742022 @default.
• W2000359574 countsByYear W20003595742023 @default.
• W2000359574 crossrefType "journal-article" @default.
• W2000359574 hasAuthorship W2000359574A5014910645 @default.
• W2000359574 hasAuthorship W2000359574A5041978411 @default.
• W2000359574 hasAuthorship W2000359574A5047600326 @default.
• W2000359574 hasAuthorship W2000359574A5047609765 @default.
• W2000359574 hasAuthorship W2000359574A5076795852 @default.
• W2000359574 hasBestOaLocation W20003595742 @default.
• W2000359574 hasConcept C104317684 @default.
• W2000359574 hasConcept C109825262 @default.
• W2000359574 hasConcept C194583182 @default.
• W2000359574 hasConcept C2777394357 @default.
• W2000359574 hasConcept C2777793812 @default.
• W2000359574 hasConcept C2780104201 @default.
• W2000359574 hasConcept C2781087480 @default.
• W2000359574 hasConcept C41282012 @default.
• W2000359574 hasConcept C53345823 @default.
• W2000359574 hasConcept C54355233 @default.
• W2000359574 hasConcept C67705224 @default.
• W2000359574 hasConcept C86803240 @default.
• W2000359574 hasConcept C95444343 @default.
• W2000359574 hasConceptScore W2000359574C104317684 @default.
• W2000359574 hasConceptScore W2000359574C109825262 @default.
• W2000359574 hasConceptScore W2000359574C194583182 @default.
• W2000359574 hasConceptScore W2000359574C2777394357 @default.
• W2000359574 hasConceptScore W2000359574C2777793812 @default.
• W2000359574 hasConceptScore W2000359574C2780104201 @default.
• W2000359574 hasConceptScore W2000359574C2781087480 @default.
• W2000359574 hasConceptScore W2000359574C41282012 @default.
• W2000359574 hasConceptScore W2000359574C53345823 @default.
• W2000359574 hasConceptScore W2000359574C54355233 @default.
• W2000359574 hasConceptScore W2000359574C67705224 @default.
• W2000359574 hasConceptScore W2000359574C86803240 @default.
• W2000359574 hasConceptScore W2000359574C95444343 @default.
• W2000359574 hasIssue "28" @default.
• W2000359574 hasLocation W20003595741 @default.
• W2000359574 hasLocation W20003595742 @default.
• W2000359574 hasLocation W20003595743 @default.
• W2000359574 hasLocation W20003595744 @default.
• W2000359574 hasOpenAccess W2000359574 @default.
• W2000359574 hasPrimaryLocation W20003595741 @default.
• W2000359574 hasRelatedWork W1899219183 @default.
• W2000359574 hasRelatedWork W2000359574 @default.

• next