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• W2000359712 abstract "You have accessJournal of UrologyProstate Cancer: Basic Research III1 Apr 2012470 EXPRESSION OF ERG ONCOPROTEIN IS LESS FREQUENTLY AND ASSOCIATED WITH A LESS AGGRESSIVE TUMOR PHENOTYPE IN JAPANESE PROSTATE CANCER PATIENTS Takahiro Kimura, Bungo Furusato, Jun Miki, Toshihiro Yamamoto, Hiroyuki Takahashi, Yuko Kamata, Geert J.H.L. van Leenders, Tapio Visakorpi, and Shin Egawa Takahiro KimuraTakahiro Kimura Tokyo, Japan More articles by this author , Bungo FurusatoBungo Furusato Tokyo, Japan More articles by this author , Jun MikiJun Miki Tokyo, Japan More articles by this author , Toshihiro YamamotoToshihiro Yamamoto Tokyo, Japan More articles by this author , Hiroyuki TakahashiHiroyuki Takahashi Tokyo, Japan More articles by this author , Yuko KamataYuko Kamata Tokyo, Japan More articles by this author , Geert J.H.L. van LeendersGeert J.H.L. van Leenders Rotterdam, Netherlands More articles by this author , Tapio VisakorpiTapio Visakorpi Tampere, Finland More articles by this author , and Shin EgawaShin Egawa Tokyo, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.539AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Gene fusion is known to be the most frequent genetic event in prostate cancer (PCa) and TMPRSS2-ERGfusion has been reported to be the most common subtype, accounting for approximately 85% of all ETS fusions and resulting in the overexpression of truncated ERG. ERG oncoprotein detected immunohistochemically using anti-ERG monoclonal antibodies has been shown to be highly specific to PCa. We previously found that a higher Gleason score correlated with ERG-positive immunostaining in a Western population. Recent reports suggest a lower incidence of TMPRSS2-ERG fusion among Asian populations, as evidenced by FISH and RT-PCR. In the current study, we investigated ERG oncoprotein expression by immunohistochemistry in a Japanese PCa cohort to further characterize its prevalence and significance. METHODS We evaluated 92 index tumors from Japanese patients who had undergone radical prostatectomy for PCa, using an antibody-based detection method to determine ERG expression. Expression status was compared with clinicopathological findings including patient age, body mass index, and preoperative prostate-specific antigen (PSA) levels, specimen Gleason score, pathological stage, positive surgical margin, size of index tumor, prostatic volume, zonal origin of index tumor, and biochemical failure. RESULTS Overall, ERG protein was expressed in 16.3% (15/92) of the index tumors, but not in benign glands (Figure). Younger patient age, lower Gleason score and negative surgical margins were found to be independently associated with its expression in the multivariate analysis (p=0.013, 0.002 and 0.028, respectively). ERG expression was not associated with biochemical failure. Though not statistically significant, ERG expression was more frequently observed in peripheral zone than in transition zone cancers (28.2% v.s. 10%, respectively). CONCLUSIONS ERG protein was less frequently expressed in this Japanese PCa cohort compared with Western reports, possibly reflecting different racial backgrounds. ERG expression was associated with a less aggressive tumor phenotype. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e192-e193 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Takahiro Kimura Tokyo, Japan More articles by this author Bungo Furusato Tokyo, Japan More articles by this author Jun Miki Tokyo, Japan More articles by this author Toshihiro Yamamoto Tokyo, Japan More articles by this author Hiroyuki Takahashi Tokyo, Japan More articles by this author Yuko Kamata Tokyo, Japan More articles by this author Geert J.H.L. van Leenders Rotterdam, Netherlands More articles by this author Tapio Visakorpi Tampere, Finland More articles by this author Shin Egawa Tokyo, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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