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• W2000360727 abstract "In vivo patterns of circulating testosterone (T) were investigated in castrated and in intact male rats following a single intramuscular injection of 1mg testosterone propionate (TP). In addition, the in vivo clearance pattern of T was investigated following castration. The injection of TP into intact rats resulted in a rapid, statistically significant increase in circulating T which lasted for 12h and returned to normal by 24h post-injection. Circulating T decreased to nondetectable levels by 6h following orchiectomy. Injection of TP into castrated rats caused a rapid increase in circulating T which reached highest levels 60 min after administration. The concentrations of T in TP-treated orchiectomized rats remained elevated for 12h with a gradual decline which persisted for the experimental period of 6 days post-injection and provided moderate maintenance of sex accessory organ weights. TP injections increased circulating T levels in both groups of rats, but the magnitude of elevation was greater in intact animals where the normal T diurnal variations were disturbed. The elevation in circulating T persisted longer in the castrate-TP-treated animals than in intact animals, suggesting a difference in clearance, distribution and metabolism of T in orchiectomized rats." @default.
• W2000360727 created "2016-06-24" @default.
• W2000360727 creator A5038858739 @default.
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• W2000360727 date "1983-07-01" @default.
• W2000360727 modified "2023-09-24" @default.
• W2000360727 title "In vivo patterns of circulating testosterone following castration and intramuscular testosterone propionate injections of adult male rats" @default.
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• W2000360727 doi "https://doi.org/10.1016/s0039-128x(83)90096-x" @default.
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