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- W2000361061 abstract "The nature of charge distributions in membrane-bound macromolecular structures renders them susceptible to interaction with transmembrane potential fields. As a result, conformational changes in such species may be expected to occur when this potential is altered. We have detected reversible conformational change in the major histocompatibility complex (MHC) class I antigen in the plasma membrane of human JY cells, as monitored by flow-cytometric resonance energy transfer, upon reduction of the transmembrane potential (depolarization). This change increased the intramolecular energy-transfer efficiency between fluorescent donor- and acceptor-labeled monoclonal antibodies directed, respectively, to epitopes on the light (β2-microglobulin) and the heavy chains of the MHC class I antigen. Repolarization of the depolarized samples restored the energy-transfer efficiency to the original values measured before depolarization. Depolarization caused similar relative changes in fluorescence resonance energy-transfer efficiency when Fab fragments were used for labeling MHC class I complex, suggesting that the observed phenomenon is not restricted to whole monoclonal antibodies. Cytometry 27:353–357, 1997. © 1997 Wiley-Liss, Inc." @default.
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- W2000361061 date "1997-04-01" @default.
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- W2000361061 title "Major histocompatibility complex class I protein conformation altered by transmembrane potential changes" @default.
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- W2000361061 doi "https://doi.org/10.1002/(sici)1097-0320(19970401)27:4<353::aid-cyto6>3.0.co;2-d" @default.
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