FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000361062> ?p ?o ?g. }

• W2000361062 endingPage "1485" @default.
• W2000361062 startingPage "1475" @default.
• W2000361062 abstract "The Aurora family of kinases, play a fundamental role in cell division and are overexpressed in several cancers including colon. The activity of barasertib-hQPA, a selective inhibitor of Aurora-B kinase (ABK) was investigated in a range of preclinical models of gastrointestinal cancer. Treatment with barasertib-hQPA produced anti-proliferative and cytotoxic effects across a panel of human colorectal cancer (CRC) cell lines in vitro. Prodrug, barasertib [48-h subcutaneous (s.c.) infusion; 150 mg/kg/day] inhibited the growth of SW620, Colo205, HCT116 human colorectal tumor xenografts in nude mice significantly (Student's t-test, P<0.05, n=10-12 per group). Flow cytometric analysis of single cells from disaggregated barasertib-treated SW620 tumors revealed a decrease in phosphorylated histone H3 (phH3) and an increase in tumor cells with ≥4N DNA content P<0.05). The activity of barasertib was then examined in ApcMin/+ mice, a spontaneous model of early intestinal neoplasia. Macroscopic evaluation of the small intestine revealed that barasertib treatment [25 mg/kg intra-peritoneal (i.p.) Q1Dx4 each week for 3 weeks] of 8-week old ApcMin/+ mice produced a 39% reduction in macroadenoma number (P=0.02) and a 43% reduction in overall adenoma burden (P=0.02) compared with vehicle-treated controls. Quantification of microscopic adenomas revealed a >64% reduction in the number of adenomas spanning more than one villus. Histological analysis of these adenomas revealed a number of distinct changes in barasertib-treated ApcMin/+ mice, including a 94% reduction in the proportion of phospho-histone H3-positive cells (P<0.001) and a 53% reduction in the number of cells per adenoma (P=0.001). These results provide a scientific rationale for investigating ABK inhibitors as a treatment for intestinal cancer." @default.
• W2000361062 created "2016-06-24" @default.
• W2000361062 creator A5010402845 @default.
• W2000361062 creator A5011521400 @default.
• W2000361062 creator A5012251107 @default.
• W2000361062 creator A5044215747 @default.
• W2000361062 creator A5055415882 @default.
• W2000361062 creator A5056697512 @default.
• W2000361062 creator A5058325442 @default.
• W2000361062 creator A5058765817 @default.
• W2000361062 creator A5068660172 @default.
• W2000361062 creator A5069898333 @default.
• W2000361062 date "2012-07-31" @default.
• W2000361062 modified "2023-10-17" @default.
• W2000361062 title "Inhibition of Aurora-B kinase activity confers antitumor efficacy in preclinical mouse models of early and advanced gastrointestinal neoplasia" @default.
• W2000361062 cites W1684202987 @default.
• W2000361062 cites W1975625207 @default.
• W2000361062 cites W1980577287 @default.
• W2000361062 cites W1989470516 @default.
• W2000361062 cites W1994488152 @default.
• W2000361062 cites W2001258296 @default.
• W2000361062 cites W2007311017 @default.
• W2000361062 cites W2018258967 @default.
• W2000361062 cites W2022581568 @default.
• W2000361062 cites W2029335488 @default.
• W2000361062 cites W2054902080 @default.
• W2000361062 cites W2059747767 @default.
• W2000361062 cites W2068268666 @default.
• W2000361062 cites W2071156666 @default.
• W2000361062 cites W2077351948 @default.
• W2000361062 cites W2084340983 @default.
• W2000361062 cites W2095327320 @default.
• W2000361062 cites W2100016325 @default.
• W2000361062 cites W2101995865 @default.
• W2000361062 cites W2104323199 @default.
• W2000361062 cites W2108670406 @default.
• W2000361062 cites W2113929218 @default.
• W2000361062 cites W2121237084 @default.
• W2000361062 cites W2125047300 @default.
• W2000361062 cites W2125052212 @default.
• W2000361062 cites W2137429755 @default.
• W2000361062 cites W2147339550 @default.
• W2000361062 cites W2149482571 @default.
• W2000361062 cites W2150695642 @default.
• W2000361062 cites W2153850465 @default.
• W2000361062 cites W2154050500 @default.
• W2000361062 cites W2154279344 @default.
• W2000361062 cites W2157828807 @default.
• W2000361062 cites W2160405431 @default.
• W2000361062 cites W2160625820 @default.
• W2000361062 cites W2161867610 @default.
• W2000361062 cites W28881088 @default.
• W2000361062 cites W4210991001 @default.
• W2000361062 doi "https://doi.org/10.3892/ijo.2012.1580" @default.
• W2000361062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22858681" @default.
• W2000361062 hasPublicationYear "2012" @default.
• W2000361062 type Work @default.
• W2000361062 sameAs 2000361062 @default.
• W2000361062 citedByCount "10" @default.
• W2000361062 countsByYear W20003610622015 @default.
• W2000361062 countsByYear W20003610622016 @default.
• W2000361062 countsByYear W20003610622017 @default.
• W2000361062 countsByYear W20003610622018 @default.
• W2000361062 countsByYear W20003610622020 @default.
• W2000361062 countsByYear W20003610622021 @default.
• W2000361062 countsByYear W20003610622023 @default.
• W2000361062 crossrefType "journal-article" @default.
• W2000361062 hasAuthorship W2000361062A5010402845 @default.
• W2000361062 hasAuthorship W2000361062A5011521400 @default.
• W2000361062 hasAuthorship W2000361062A5012251107 @default.
• W2000361062 hasAuthorship W2000361062A5044215747 @default.
• W2000361062 hasAuthorship W2000361062A5055415882 @default.
• W2000361062 hasAuthorship W2000361062A5056697512 @default.
• W2000361062 hasAuthorship W2000361062A5058325442 @default.
• W2000361062 hasAuthorship W2000361062A5058765817 @default.
• W2000361062 hasAuthorship W2000361062A5068660172 @default.
• W2000361062 hasAuthorship W2000361062A5069898333 @default.
• W2000361062 hasBestOaLocation W20003610621 @default.
• W2000361062 hasConcept C121608353 @default.
• W2000361062 hasConcept C126322002 @default.
• W2000361062 hasConcept C142724271 @default.
• W2000361062 hasConcept C184235292 @default.
• W2000361062 hasConcept C2777428134 @default.
• W2000361062 hasConcept C2781018059 @default.
• W2000361062 hasConcept C29537977 @default.
• W2000361062 hasConcept C502942594 @default.
• W2000361062 hasConcept C526805850 @default.
• W2000361062 hasConcept C542804219 @default.
• W2000361062 hasConcept C55493867 @default.
• W2000361062 hasConcept C62112901 @default.
• W2000361062 hasConcept C67082663 @default.
• W2000361062 hasConcept C71924100 @default.
• W2000361062 hasConcept C86803240 @default.
• W2000361062 hasConceptScore W2000361062C121608353 @default.
• W2000361062 hasConceptScore W2000361062C126322002 @default.
• W2000361062 hasConceptScore W2000361062C142724271 @default.
• W2000361062 hasConceptScore W2000361062C184235292 @default.
• W2000361062 hasConceptScore W2000361062C2777428134 @default.

• next