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- W2000361185 abstract "Postmenopausal osteoporosis in women is the result of decline in synthesis of ovarian hormone estrogen, leading to reduced bone mass and increased bone turnover. Estrogen deficiency also affects antioxidant status in the body by production of reactive oxygen species. Continuous synthesis of reactive oxygen species damages the bone and enhances osteoclastogenesis. Irrespective of the therapy followed, Calcium, Vitamin D and Zinc are prescribed for osteoporosis. Osteoporosis being multifactorial disease in nature, only calcium and vitamin D supplement fails to make up for the bone loss. We addressed this problem by formulating treatments targeting various factors involved in the progression of osteoporosis by supplementing amino acids, genestein isoflavones and Vitamin K2. Increased oxidant status and decreased antioxidants enzymes were observed in OVX group followed by reversing effect in treatment groups enabling to understand that bone mineralizing nutrients and minerals seem to show positive effect on ovariectomy induced oxidative damage." @default.
- W2000361185 created "2016-06-24" @default.
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- W2000361185 date "2014-12-15" @default.
- W2000361185 modified "2023-09-27" @default.
- W2000361185 title "Effect of Nutritional Intervention Treatment for Ovx Induced Osteoporosis on Oxidant-Antioxidant Status in Female Wistar Rats" @default.
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- W2000361185 doi "https://doi.org/10.6084/m9.figshare.1270586" @default.
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