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• W2000361482 endingPage "2071" @default.
• W2000361482 startingPage "2058" @default.
• W2000361482 abstract "Myeloid-derived suppressor cells (MDSCs) have been characterized in several disease settings, especially in many tumor systems. Compared to their involvement in tumor microenvironments, however, MDSCs have been less well studied in their responses to infectious disease processes, in particular to retroviruses that induce immunodeficiency. Here, we demonstrate for the first time the development of a highly immunosuppressive MDSC population that is dependent on infection by the LP-BM5 retrovirus, which causes murine acquired immunodeficiency. These MDSCs express a cell surface marker signature (CD11b(+) Gr-1(+) Ly6C(+)) characteristic of monocyte-type MDSCs. Such MDSCs profoundly inhibit immune responsiveness by a cell dose- and substantially inducible nitric oxide synthase (iNOS)-dependent mechanism that is independent of arginase activity, PD-1-PD-L1 expression, and interleukin 10 (IL-10) production. These MDSCs display levels of immunosuppressive function in parallel with the extent of disease in LP-BM5-infected wild-type (w.t.) versus knockout mouse strains that are differentially susceptible to pathogenesis. These MDSCs suppressed not only T-cell but also B-cell responses, which are an understudied target for MDSC inhibition. The MDSC immunosuppression of B-cell responses was confirmed by the use of purified B responder cells, multiple B-cell stimuli, and independent assays measuring B-cell expansion. Retroviral load measurements indicated that the suppressive Ly6G(low/±) Ly6C(+) CD11b(+)-enriched MDSC subset was positive for LP-BM5, albeit at a significantly lower level than that of nonfractionated splenocytes from LP-BM5-infected mice. These results, including the strong direct MDSC inhibition of B-cell responsiveness, are novel for murine retrovirus-induced immunosuppression and, as this broadly suppressive function mirrors that of the LP-BM5-induced disease syndrome, support a possible pathogenic effector role for these retrovirus-induced MDSCs." @default.
• W2000361482 created "2016-06-24" @default.
• W2000361482 creator A5044528603 @default.
• W2000361482 creator A5049644755 @default.
• W2000361482 creator A5071281003 @default.
• W2000361482 date "2013-02-15" @default.
• W2000361482 modified "2023-10-16" @default.
• W2000361482 title "Myeloid-Derived Suppressor Cells in Murine Retrovirus-Induced AIDS Inhibit T- and B-Cell Responses <i>In Vitro</i> That Are Used To Define the Immunodeficiency" @default.
• W2000361482 cites W1506927838 @default.
• W2000361482 cites W1536028944 @default.
• W2000361482 cites W1541892895 @default.
• W2000361482 cites W1551777364 @default.
• W2000361482 cites W1562163928 @default.
• W2000361482 cites W1563013015 @default.
• W2000361482 cites W1569117171 @default.
• W2000361482 cites W1624894109 @default.
• W2000361482 cites W1678412754 @default.
• W2000361482 cites W1952244035 @default.
• W2000361482 cites W1955031859 @default.
• W2000361482 cites W1963706053 @default.
• W2000361482 cites W1969901909 @default.
• W2000361482 cites W1976310228 @default.
• W2000361482 cites W1977179270 @default.
• W2000361482 cites W1978436252 @default.
• W2000361482 cites W1985077359 @default.
• W2000361482 cites W1985537719 @default.
• W2000361482 cites W1990148591 @default.
• W2000361482 cites W1996743080 @default.
• W2000361482 cites W2000154274 @default.
• W2000361482 cites W2003481607 @default.
• W2000361482 cites W2004150448 @default.
• W2000361482 cites W2004998289 @default.
• W2000361482 cites W2011627030 @default.
• W2000361482 cites W2013013791 @default.
• W2000361482 cites W2014015430 @default.
• W2000361482 cites W2014963034 @default.
• W2000361482 cites W2016354161 @default.
• W2000361482 cites W2021579239 @default.
• W2000361482 cites W2021797118 @default.
• W2000361482 cites W2021992999 @default.
• W2000361482 cites W2023164440 @default.
• W2000361482 cites W2023763412 @default.
• W2000361482 cites W2025429032 @default.
• W2000361482 cites W2025455299 @default.
• W2000361482 cites W2025521783 @default.
• W2000361482 cites W2026268116 @default.
• W2000361482 cites W2027880583 @default.
• W2000361482 cites W2028780839 @default.
• W2000361482 cites W2030335403 @default.
• W2000361482 cites W2035852466 @default.
• W2000361482 cites W2036500213 @default.
• W2000361482 cites W2039386737 @default.
• W2000361482 cites W2042546551 @default.
• W2000361482 cites W2050074438 @default.
• W2000361482 cites W2057132697 @default.
• W2000361482 cites W2058798829 @default.
• W2000361482 cites W2063874265 @default.
• W2000361482 cites W2073906172 @default.
• W2000361482 cites W2074640200 @default.
• W2000361482 cites W2076819781 @default.
• W2000361482 cites W2080643918 @default.
• W2000361482 cites W2086168252 @default.
• W2000361482 cites W2086455774 @default.
• W2000361482 cites W2090172091 @default.
• W2000361482 cites W2090219407 @default.
• W2000361482 cites W2090672759 @default.
• W2000361482 cites W2095040060 @default.
• W2000361482 cites W2095455162 @default.
• W2000361482 cites W2096837743 @default.
• W2000361482 cites W2097855813 @default.
• W2000361482 cites W2097877316 @default.
• W2000361482 cites W2098494951 @default.
• W2000361482 cites W2100070721 @default.
• W2000361482 cites W2104357791 @default.
• W2000361482 cites W2105372977 @default.
• W2000361482 cites W2111102610 @default.
• W2000361482 cites W2111642820 @default.
• W2000361482 cites W2115853040 @default.
• W2000361482 cites W2115923268 @default.
• W2000361482 cites W2117820020 @default.
• W2000361482 cites W2119146367 @default.
• W2000361482 cites W2121681687 @default.
• W2000361482 cites W2125558391 @default.
• W2000361482 cites W2125644509 @default.
• W2000361482 cites W2133052855 @default.
• W2000361482 cites W2134837867 @default.
• W2000361482 cites W2135698322 @default.
• W2000361482 cites W2138582495 @default.
• W2000361482 cites W2139062712 @default.
• W2000361482 cites W2141383323 @default.
• W2000361482 cites W2143251754 @default.
• W2000361482 cites W2149912273 @default.
• W2000361482 cites W2151277992 @default.
• W2000361482 cites W2151551477 @default.
• W2000361482 cites W2151583712 @default.
• W2000361482 cites W2154381591 @default.
• W2000361482 cites W2155464294 @default.
• W2000361482 cites W2156915900 @default.

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