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- W2000361812 abstract "Summary The contribution of post-burn hypothermia to alterations in carbohydrate metabolism was investigated at 4, 8 and 24 h following a 27 per cent body surface scald produced in rats previously fasted for 24 h. Fasted control animals were evaluated at the same time intervals as the burned animals. Following burn injury, body temperature fell to 31·3 ± 0·3 °C (± s.e.) at 4 h and returned to control values by 24 h post burn. At each time interval, serum glucose was 2-fold higher, serum corticosterone was more than 4-fold higher and plasma glucagon was more than 2-fold higher than corresponding controls. Serum insulin did not differ from controls at 4 h, but then rose linearly to a value almost 5-fold higher than the control value at 24 h post burn. The addition of 20 mmol alanine to liver slices from rats 4 h post burn and controls incubated at 37 °C increased glucose production in vitro , the effect being greater in burned rats. In contrast, liver slices from burned and control rats did not convert alanine to glucose (or tissue glycogen) when incubated at the body temperature of rats 4 h post burn — 31 °C. The addition of insulin in vitro produced a similar increase in glucose uptake by soleus muscle from both rats 4-h post burn and controls when incubated at 37 °C, but the effect was significantly reduced in both groups of muscles when incubated at 31 °C. The data suggest that post-burn hypothermia modifies the metabolic response to injury by opposing the stimulation of gluconeogenesis and that it is the direct cause of decreased sensitivity to insulin observed acutely after the experimental burn." @default.
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- W2000361812 date "1980-06-01" @default.
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- W2000361812 title "The role of hypothermia in gluconeogenesis and sensitivity to insulin after burns" @default.
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- W2000361812 doi "https://doi.org/10.1016/s0305-4179(80)80002-7" @default.
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