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• W2000361836 abstract "Abstract Malonaldehyde (MA), a product of lipid peroxidation, is known to have a number of toxicological effects. Among skin surface components, squalene has been suggested as a significant source of MA following UV exposure. Irradiation of squalene coated on the inside surface of glass tubes served as a simple model to examine skin surface photochemistry. Malonaldehyde produced during UV-irradiation was reacted with methyl hydrazine to form N-methylpyrazole, which was then measured by gas chromatographic analysis. Ultraviolet A-irradiation produced low levels of MA from squalene, with a maximum of 1.0 nmol MA/µmol squalene near 6 h. Malonaldehyde production varied with the energy of irradiation, with levels of 176 nmol/mg squalene and 9 nmol/mg squalene produced after 3 h of irradiation with UVB and UVA, respectively. The thiobarbituric acid (TBA) assay for lipid peroxidation showed large overestimations of MA levels under all irradiation conditions tested. The TBA assay predicted the highest levels of MA with UVC but we did not detect any MA with our assay." @default.
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• W2000361836 date "1989-05-01" @default.
• W2000361836 modified "2023-09-26" @default.
• W2000361836 title "PRODUCTION OF MALONALDEHYDE FROM SQUALENE, A MAJOR SKIN SURFACE LIPID, DURING UV-IRRADIATION" @default.
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• W2000361836 doi "https://doi.org/10.1111/j.1751-1097.1989.tb08445.x" @default.
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