Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000362162> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2000362162 endingPage "1441" @default.
- W2000362162 startingPage "1439" @default.
- W2000362162 abstract "Topoisomerase II modulates DNA topology by generating double-stranded breaks in DNA. Results of the current study indicate that the presence of a nick at one scissile bond dramatically increases the rate of cleavage by human topoisomerase IIα at the scissile bond on the opposite strand. We propose that this enhanced activity at the second strand coordinates the two protomer subunits of topoisomerase II and allows the enzyme to create double-stranded breaks. Finally, the presence of a nick on one strand induces cleavage on the opposite strand. Thus, nicks are topoisomerase II poisons that generate novel sites of DNA cleavage." @default.
- W2000362162 created "2016-06-24" @default.
- W2000362162 creator A5041320360 @default.
- W2000362162 creator A5072616043 @default.
- W2000362162 date "2009-01-23" @default.
- W2000362162 modified "2023-09-23" @default.
- W2000362162 title "Coordinating the Two Protomer Active Sites of Human Topoisomerase IIα: Nicks as Topoisomerase II Poisons" @default.
- W2000362162 cites W1542531535 @default.
- W2000362162 cites W1555798239 @default.
- W2000362162 cites W1965326858 @default.
- W2000362162 cites W1975319188 @default.
- W2000362162 cites W1975483620 @default.
- W2000362162 cites W1978161781 @default.
- W2000362162 cites W1995421049 @default.
- W2000362162 cites W2004802580 @default.
- W2000362162 cites W2050407942 @default.
- W2000362162 cites W2069151403 @default.
- W2000362162 cites W2091999358 @default.
- W2000362162 cites W2115330976 @default.
- W2000362162 cites W2124624490 @default.
- W2000362162 cites W2125527869 @default.
- W2000362162 cites W2132600317 @default.
- W2000362162 cites W4239498422 @default.
- W2000362162 doi "https://doi.org/10.1021/bi8021679" @default.
- W2000362162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2716134" @default.
- W2000362162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19166355" @default.
- W2000362162 hasPublicationYear "2009" @default.
- W2000362162 type Work @default.
- W2000362162 sameAs 2000362162 @default.
- W2000362162 citedByCount "25" @default.
- W2000362162 countsByYear W20003621622012 @default.
- W2000362162 countsByYear W20003621622014 @default.
- W2000362162 countsByYear W20003621622015 @default.
- W2000362162 countsByYear W20003621622016 @default.
- W2000362162 countsByYear W20003621622017 @default.
- W2000362162 countsByYear W20003621622018 @default.
- W2000362162 countsByYear W20003621622019 @default.
- W2000362162 countsByYear W20003621622020 @default.
- W2000362162 countsByYear W20003621622021 @default.
- W2000362162 countsByYear W20003621622022 @default.
- W2000362162 crossrefType "journal-article" @default.
- W2000362162 hasAuthorship W2000362162A5041320360 @default.
- W2000362162 hasAuthorship W2000362162A5072616043 @default.
- W2000362162 hasBestOaLocation W20003621622 @default.
- W2000362162 hasConcept C147897179 @default.
- W2000362162 hasConcept C151730666 @default.
- W2000362162 hasConcept C161790260 @default.
- W2000362162 hasConcept C175156509 @default.
- W2000362162 hasConcept C181199279 @default.
- W2000362162 hasConcept C185592680 @default.
- W2000362162 hasConcept C3044715 @default.
- W2000362162 hasConcept C41183919 @default.
- W2000362162 hasConcept C43369102 @default.
- W2000362162 hasConcept C552990157 @default.
- W2000362162 hasConcept C55493867 @default.
- W2000362162 hasConcept C71240020 @default.
- W2000362162 hasConcept C86803240 @default.
- W2000362162 hasConcept C87282627 @default.
- W2000362162 hasConceptScore W2000362162C147897179 @default.
- W2000362162 hasConceptScore W2000362162C151730666 @default.
- W2000362162 hasConceptScore W2000362162C161790260 @default.
- W2000362162 hasConceptScore W2000362162C175156509 @default.
- W2000362162 hasConceptScore W2000362162C181199279 @default.
- W2000362162 hasConceptScore W2000362162C185592680 @default.
- W2000362162 hasConceptScore W2000362162C3044715 @default.
- W2000362162 hasConceptScore W2000362162C41183919 @default.
- W2000362162 hasConceptScore W2000362162C43369102 @default.
- W2000362162 hasConceptScore W2000362162C552990157 @default.
- W2000362162 hasConceptScore W2000362162C55493867 @default.
- W2000362162 hasConceptScore W2000362162C71240020 @default.
- W2000362162 hasConceptScore W2000362162C86803240 @default.
- W2000362162 hasConceptScore W2000362162C87282627 @default.
- W2000362162 hasIssue "7" @default.
- W2000362162 hasLocation W20003621621 @default.
- W2000362162 hasLocation W20003621622 @default.
- W2000362162 hasLocation W20003621623 @default.
- W2000362162 hasLocation W20003621624 @default.
- W2000362162 hasOpenAccess W2000362162 @default.
- W2000362162 hasPrimaryLocation W20003621621 @default.
- W2000362162 hasRelatedWork W1967948506 @default.
- W2000362162 hasRelatedWork W1975319188 @default.
- W2000362162 hasRelatedWork W1987304954 @default.
- W2000362162 hasRelatedWork W2000362162 @default.
- W2000362162 hasRelatedWork W2003405523 @default.
- W2000362162 hasRelatedWork W2043644749 @default.
- W2000362162 hasRelatedWork W2053120620 @default.
- W2000362162 hasRelatedWork W2086695915 @default.
- W2000362162 hasRelatedWork W2125527869 @default.
- W2000362162 hasRelatedWork W2757279783 @default.
- W2000362162 hasVolume "48" @default.
- W2000362162 isParatext "false" @default.
- W2000362162 isRetracted "false" @default.
- W2000362162 magId "2000362162" @default.
- W2000362162 workType "article" @default.