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• W2000362259 abstract "A total of 162 clinical isolates of Shigella collected from children in a semi-rural community of Chile were examined for the presence of genetic determinants of resistance to ampicillin, chloramphenicol, tetracycline, and trimethoprim. Ampicillin resistance was most frequently associated with the presence of bla OXA in S. flexneri and with bla TEM in S. sonnei . The bla OXA gene but not bla TEM was located in class 1 integrons. The dhfr Ia gene encoding for resistance to trimethoprim was associated to class 2 integrons and detected exclusively in S. flexneri , whereas dhfr IIIc was found in all S. sonnei strains and in 10% of the S. flexneri isolates. Cat , coding for choramphenicol resistance, and bla OXA genes were located in the chromosome in all cases, whereas tetA gene, coding for tetracycline resistance, and bla TEM , dhfr Ia and dhfr IIIc genes were found either in the chromosome or in conjugative plasmids. Our results show a heterogenous distribution of antibiotic-resistance determinants between S. flexneri and S. sonnei ." @default.
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• W2000362259 date "2004-10-06" @default.
• W2000362259 modified "2023-10-01" @default.
• W2000362259 title "Genetic analysis of antibiotic-resistance determinants in multidrug-resistant <i>Shigella</i> strains isolated from Chilean children" @default.
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• W2000362259 doi "https://doi.org/10.1017/s0950268804003048" @default.
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