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- W2000362394 abstract "In this study we revealed the participation of P2X7 receptors in the modulation of electrical stimulation and ATP-evoked GABA and glutamate release from mouse hippocampal slices. Whereas the uptake of radioactivity was not changed, the electrical stimulation-induced release of both [3H]glutamate and [3H]GABA was decreased in the hippocampus of P2X7 receptor-deficient mice. ATP (10 mM) elicited [3H]glutamate and [3H]GABA efflux in wild-type mice, which was inhibited by the non-selective P2 receptor antagonist pyridoxal-phosphate-6-azophenyl-2′,4′-disulphonic acid tetrasodium (30 μM) and the P2X7-selective antagonist Brilliant Blue G (1 μM). The ATP-evoked release of both GABA and glutamate was virtually absent in the knockout mice. These results indicate that ATP facilitates GABA and glutamate release in the hippocampus by a mechanism involving P2X7R." @default.
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- W2000362394 date "2004-10-01" @default.
- W2000362394 modified "2023-10-16" @default.
- W2000362394 title "Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor−/− mice" @default.
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- W2000362394 doi "https://doi.org/10.1097/00001756-200410250-00017" @default.
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