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• W2000362434 abstract "During the spontaneous or thyroid hormone (TH)-induced metamorphosis of Rana catesbeiana, developmental changes occur in its liver that are necessary for the transition of this organism from an ammonotelic larva to a ureotelic adult. These changes include the coordinated expression of genes encoding the urea cycle enzymes carbamyl phosphate synthetase (CPS-I) and arnithine transcarbamylase (OTC). Although the expression of these genes is dependent on TH, the mechanisms(s) by which TH initiates this tissue-specific response is thought to be indirect and to involve early TH-induced upregulation of a gene(s), which, in turn, upregulates the coordinated expression of these urea-cycle enzyme genes. Herein, we demonstrate that mRNAs encoding the Rana homologue of the mammalian transcription factor C/EBP alpha (designated RcC/EBP-1) accumulate early in response to TH and that the product of these mRNAs can bind to and transactivate the promoters of both the Rana CPS-1 and OTC genes. These results support the contention that the reprogramming of gene expression in the liver of metamorphosing tadpoles involves a TH-induced cascade of gene activity in which RcC/EBP-1 and, perhaps, other transcription factors coordinate the expression of genes, such as those encoding CPS-I and OTC, whose products are characteristic of the adult liver phenotype." @default.
• W2000362434 created "2016-06-24" @default.
• W2000362434 creator A5015965665 @default.
• W2000362434 creator A5085971155 @default.
• W2000362434 date "1997-01-01" @default.
• W2000362434 modified "2023-10-16" @default.
• W2000362434 title "Role for theRana catesbeiana homologue of C/EBP α in the reprogramming of gene expression in the liver of metamorphosing tadpoles" @default.
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• W2000362434 doi "https://doi.org/10.1002/(sici)1520-6408(1997)20:2<152::aid-dvg8>3.0.co;2-6" @default.
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