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- W2000363852 abstract "In this issue of the Cancer Treatment and Research, Park et al (1) presented a prospective study on the efficacy and toxicity of combined chemoradiotherapy delivered preoperatively for locally advanced rectal cancer. The role of concurrent chemoradiotherapy in stage II and III rectal cancer has been established by postoperative chemoradiation treatment. While efforts to compare the efficacy and toxicity of preoperative versus postoperative concurrent chemoradiation treatment in phase III trials in the United States have been largely unsuccessful, due to a poor patient accrual rate, a German trial has shown a benefit in pelvic control with preoperative chemoradiation compared to postoperative chemoradiation (2). Furthermore, the Swedish Rectal Trial Group have shown benefits in both pelvic control and overall survival with preoperative radiotherapy alone. A randomized trial has not yet been completed comparing the role of preoperative chemoradiotherapy to radiation alone. However, the rationale for preoperative concurrent chemoradiotherapy is based on extrapolation from postoperative trials. The advantages of preoperative over postoperative treatment include; less acute toxicity and an increased sphincter preservation rate. The most significant disadvantages of preoperative treatment are that a certain fraction of patients will be treated unnecessarily due to the inaccuracy of clinical staging, which will result in treatment failure due to inherited treatment resistance." @default.
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- W2000363852 date "2004-01-01" @default.
- W2000363852 modified "2023-10-02" @default.
- W2000363852 title "Preoperative Concurrent Chemoradiotherapy with Oral Fluoropyrimidine in Locally Advanced Rectal Cancer: How Good Is Good Enough?" @default.
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- W2000363852 doi "https://doi.org/10.4143/crt.2004.36.6.341" @default.
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