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- W2000364565 abstract "Previous studies on the piglet colon in newborns cleared of bacterial metabolic activity showed a capacity for lactose absorption. Colonic absorption occurred at a flux rate equal to the assimilation of lactose by the small intestine but by a process that did not involve either glucose-galactose sodium cotransport or simple diffusion. Surprisingly, colonic lactose transport did not require either fermentation or cleavage of the disaccharide for uptake. Experiments were designed to test the selectivity of the colonic transport process for a variety of carbohydrates. Colonic tissues from 4-7-d-old piglets were mounted in Ussing chambers and the mucosal-to-serosal flux of radiolabeled carbohydrates was compared with that of lactose. The results showed a 3-4-fold greater flux of galactose-containing sugars as compared with glucose-containing carbohydrates at concentrations up to 40 mM. Even lactulose, a synthetic disaccharide assumed to require bacterial digestion before assimilation, was transported readily.N-Acetylgalactosamine, a component of colonic mucus, inhibited the flux of lactose, whereas N-acetylglucosamine did not. Similarly, lactosylated BSA inhibited lactose flux, whereas nonlactosylated BSA did not. The capacity of the colon of the newborn to differentiate moieties as similar as glucose and galactose suggests an absorptive process for carbohydrates with a high degree of discrimination." @default.
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- W2000364565 date "1996-04-01" @default.
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- W2000364565 title "Galactose-Containing Carbohydrates Are Preferentially Absorbed in the Neonatal Pig Colon" @default.
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- W2000364565 doi "https://doi.org/10.1203/00006450-199604000-00016" @default.
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