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- W2000364836 abstract "Free and ester forms of cholesterol 7α- and 7β-hydroperoxides (Ch 7-OOHs) in skin lipids of humans were separated and determined by high performance liquid chromatography with a chemiluminescence detector. We first demonstrated the presence of Ch 7-OOHs in lipids of human skin. The levels of Ch 7-OOHs found in skin lipids of healthy Japanese volunteers (n = 5) ranged from 2.78 to 25.2 pmol/cm2 skin, indicating large inter-individual differences. However, the intra-individual differences of Ch 7-OOHs levels in skin lipids between right and left arms were less than 25% (−16.4% to 24.0%). Inter-day differences of Ch 7-OOHs in 5 subjects at 1 week interval were also small (−36.7% to 47.7%). Additionally, we investigated effects of sunlight exposure on the levels of Ch 7-OOHs in skin lipids of healthy Japanese volunteers (n = 24). The levels of Ch 7-OOHs in skin lipids significantly increased from 10.0 ± 6.7 to 38.9 ± 38.0 pmol/cm2 skin by sunlight exposure (10–40 mJ/cm2/min) for 3 h. Therefore, natural sunlight exposure causes lipid peroxidation in skin lipids of humans. These results suggest that the level of Ch 7-OOHs is a good marker for lipid peroxidation in human skin." @default.
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- W2000364836 date "1999-05-01" @default.
- W2000364836 modified "2023-09-23" @default.
- W2000364836 title "Increases in cholesterol 7-hydroperoxides in lipids of human skin by sunlight exposure" @default.
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- W2000364836 doi "https://doi.org/10.1016/s0891-5849(98)00295-0" @default.
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