FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000365319> ?p ?o ?g. }

• W2000365319 endingPage "86" @default.
• W2000365319 startingPage "78" @default.
• W2000365319 abstract "Human adenovirus Ad-36 causes adiposity in animal models and shows association with human obesity. Ad-36 enhances differentiation of 3T3-L1 and human preadipocytes, without cell lysis, a characteristic that may contribute to its adipogenic effect observed in vivo. Ad-2, another human adenovirus is nonadipogenic in animals and in 3T3-L1 cells and shows no correlation with human obesity. The objective of this study was to determine the adipogenic roles of viral mRNA and DNA, which may explain the differential effects of Ad-36 and Ad-2 on preadipocyte differentiation. This study determined the duration of selected Ad-36 gene expression in 3T3-L1 cells, and the effect on preadipocytes differentiation, when Ad-36 gene expression was attenuated by Cidofovir, an antiadenoviral agent. The results showed that Ad-36, but not Ad-2, expresses viral mRNA. Ad-36 gene expression peaked at 2–4 days postinoculation and very low levels persisted after day 7. Despite the viral mRNA expression, Ad-36 infection of 3T3-L1 cells was abortive as indicated by a progressive decrease in viral DNA quantity. Attenuation of Ad-36 mRNA expression by Cidofovir reduced the adipogenic effect of the virus. In conclusion, viral mRNA expression, although transient, is a prerequisite for enhancing differentiation of preadipocytes by Ad-36. Viral DNA replication was not required for the effect. This is the first evidence for the role of gene expression of an adipogenic human virus in enhancing preadipocytes differentiation. This study provides the basis for further understanding novel regulatory modulators of preadipocytes differentiation." @default.
• W2000365319 created "2016-06-24" @default.
• W2000365319 creator A5007364549 @default.
• W2000365319 creator A5014383282 @default.
• W2000365319 creator A5029343475 @default.
• W2000365319 creator A5041386955 @default.
• W2000365319 creator A5077475196 @default.
• W2000365319 creator A5078242382 @default.
• W2000365319 date "2006-05-02" @default.
• W2000365319 modified "2023-10-16" @default.
• W2000365319 title "Viral mRNA expression but not DNA replication is required for lipogenic effect of human adenovirus Ad-36 in preadipocytes" @default.
• W2000365319 cites W1510986852 @default.
• W2000365319 cites W1556721384 @default.
• W2000365319 cites W1815087127 @default.
• W2000365319 cites W1924240621 @default.
• W2000365319 cites W1967939624 @default.
• W2000365319 cites W1986919040 @default.
• W2000365319 cites W1987406457 @default.
• W2000365319 cites W1997079696 @default.
• W2000365319 cites W2003978407 @default.
• W2000365319 cites W2013219143 @default.
• W2000365319 cites W2015663340 @default.
• W2000365319 cites W2028109071 @default.
• W2000365319 cites W2053881520 @default.
• W2000365319 cites W2058177872 @default.
• W2000365319 cites W2058642356 @default.
• W2000365319 cites W2062756228 @default.
• W2000365319 cites W2065276626 @default.
• W2000365319 cites W2079714141 @default.
• W2000365319 cites W2094607573 @default.
• W2000365319 cites W2109584224 @default.
• W2000365319 cites W2138312465 @default.
• W2000365319 cites W2138468637 @default.
• W2000365319 cites W2151686684 @default.
• W2000365319 cites W2158573664 @default.
• W2000365319 cites W90840010 @default.
• W2000365319 doi "https://doi.org/10.1038/sj.ijo.0803358" @default.
• W2000365319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16652125" @default.
• W2000365319 hasPublicationYear "2006" @default.
• W2000365319 type Work @default.
• W2000365319 sameAs 2000365319 @default.
• W2000365319 citedByCount "41" @default.
• W2000365319 countsByYear W20003653192012 @default.
• W2000365319 countsByYear W20003653192013 @default.
• W2000365319 countsByYear W20003653192014 @default.
• W2000365319 countsByYear W20003653192015 @default.
• W2000365319 countsByYear W20003653192016 @default.
• W2000365319 countsByYear W20003653192018 @default.
• W2000365319 countsByYear W20003653192020 @default.
• W2000365319 countsByYear W20003653192022 @default.
• W2000365319 countsByYear W20003653192023 @default.
• W2000365319 crossrefType "journal-article" @default.
• W2000365319 hasAuthorship W2000365319A5007364549 @default.
• W2000365319 hasAuthorship W2000365319A5014383282 @default.
• W2000365319 hasAuthorship W2000365319A5029343475 @default.
• W2000365319 hasAuthorship W2000365319A5041386955 @default.
• W2000365319 hasAuthorship W2000365319A5077475196 @default.
• W2000365319 hasAuthorship W2000365319A5078242382 @default.
• W2000365319 hasBestOaLocation W20003653191 @default.
• W2000365319 hasConcept C104317684 @default.
• W2000365319 hasConcept C105580179 @default.
• W2000365319 hasConcept C122927707 @default.
• W2000365319 hasConcept C134018914 @default.
• W2000365319 hasConcept C140704245 @default.
• W2000365319 hasConcept C148738053 @default.
• W2000365319 hasConcept C150194340 @default.
• W2000365319 hasConcept C153911025 @default.
• W2000365319 hasConcept C159047783 @default.
• W2000365319 hasConcept C171089720 @default.
• W2000365319 hasConcept C2522874641 @default.
• W2000365319 hasConcept C54355233 @default.
• W2000365319 hasConcept C86803240 @default.
• W2000365319 hasConceptScore W2000365319C104317684 @default.
• W2000365319 hasConceptScore W2000365319C105580179 @default.
• W2000365319 hasConceptScore W2000365319C122927707 @default.
• W2000365319 hasConceptScore W2000365319C134018914 @default.
• W2000365319 hasConceptScore W2000365319C140704245 @default.
• W2000365319 hasConceptScore W2000365319C148738053 @default.
• W2000365319 hasConceptScore W2000365319C150194340 @default.
• W2000365319 hasConceptScore W2000365319C153911025 @default.
• W2000365319 hasConceptScore W2000365319C159047783 @default.
• W2000365319 hasConceptScore W2000365319C171089720 @default.
• W2000365319 hasConceptScore W2000365319C2522874641 @default.
• W2000365319 hasConceptScore W2000365319C54355233 @default.
• W2000365319 hasConceptScore W2000365319C86803240 @default.
• W2000365319 hasIssue "1" @default.
• W2000365319 hasLocation W20003653191 @default.
• W2000365319 hasLocation W20003653192 @default.
• W2000365319 hasOpenAccess W2000365319 @default.
• W2000365319 hasPrimaryLocation W20003653191 @default.
• W2000365319 hasRelatedWork W1889378448 @default.
• W2000365319 hasRelatedWork W2006248782 @default.
• W2000365319 hasRelatedWork W2060978273 @default.
• W2000365319 hasRelatedWork W2084245009 @default.
• W2000365319 hasRelatedWork W2780019192 @default.
• W2000365319 hasRelatedWork W3169375705 @default.
• W2000365319 hasRelatedWork W3177859811 @default.
• W2000365319 hasRelatedWork W3217615580 @default.

• next