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- W2000365513 abstract "Significance We show the histone mark H3K9me2, which is known to mediate transposon silencing, to determine the choice between alternative polyadenylation sites within the Arabidopsis thaliana disease resistance gene RPP7 . High H3K9me2 levels recruited to the first RPP7 intron by the COPIA-R7 retrotransposon suppress use of a promoter-proximal polyadenylation site. Modulating H3K9me2 levels at this site shifts the balance between full-length and incomplete RPP7 transcripts. By recruiting H3K9me2-dependent polyadenylation control to RPP7 , the COPIA-R7 insertion provided a new switch to fine-tune RPP7 expression. Selective advantages resulting from this mechanism likely contributed to the domestication of COPIA-R7 at RPP7 ." @default.
- W2000365513 created "2016-06-24" @default.
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- W2000365513 date "2013-08-12" @default.
- W2000365513 modified "2023-10-15" @default.
- W2000365513 title "An alternative polyadenylation mechanism coopted to the <i>Arabidopsis RPP7</i> gene through intronic retrotransposon domestication" @default.
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- W2000365513 doi "https://doi.org/10.1073/pnas.1312545110" @default.
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