Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000366357> ?p ?o ?g. }
- W2000366357 endingPage "361" @default.
- W2000366357 startingPage "354" @default.
- W2000366357 abstract "While type 1 diabetes and type 2 diabetes (T2D) are considered etiologically distinct, mixed features of autoimmunity and insulin resistance are increasingly common. We explored a familial contribution to this admixture by evaluating diabetes family history (FH) and its relationship to diabetes type, ethnicity, age at diagnosis, and cardiovascular risk factors in SEARCH for Diabetes in Youth Study participants.Diabetes FH was assessed by questionnaire, with FH categories defined by relative's(s') age at diagnosis as follows: <25 (early FH), >/=25 (later FH), and both <25 and >/=25 (mixed FH). Diabetes type was classified based on a biochemical algorithm using diabetes autoantibodies and fasting C-peptide (FCP).A positive FH was common in all diabetes types, particularly T2D (83%). Minorities were more likely to have a positive FH than non-Hispanic Whites [odds ratio (OR) 1.96, 95% confidence interval (CI) 1.69-2.27]. The likelihood of having an early FH decreased with age at diagnosis (OR 0.95, 95% CI 0.93-0.98), and the likelihood of having a later/mixed or any positive FH increased with age (OR 1.03, 95% CI 1.01-1.04; OR 1.03, 95% CI 1.02-1.05, respectively). Higher FCP concentrations and less desirable values for almost all cardiovascular risk factors were associated with a later/mixed FH. The association between a later/mixed FH and FCP, body mass index, waist circumference, triglycerides, and high-density lipoprotein remained significant in a subgroup of autoimmune participants.Later FH confers cardiovascular risk factors in diabetic youth, including those youth with islet cell autoimmunity. This characterization of diabetes FH may provide a better understanding of familial contributors to diabetes." @default.
- W2000366357 created "2016-06-24" @default.
- W2000366357 creator A5027771126 @default.
- W2000366357 creator A5031187973 @default.
- W2000366357 creator A5034609462 @default.
- W2000366357 creator A5035421263 @default.
- W2000366357 creator A5035584432 @default.
- W2000366357 creator A5037503691 @default.
- W2000366357 creator A5040740270 @default.
- W2000366357 creator A5089972335 @default.
- W2000366357 date "2007-12-01" @default.
- W2000366357 modified "2023-10-13" @default.
- W2000366357 title "Family history of diabetes, autoimmunity, and risk factors for cardiovascular disease among children with diabetes in the SEARCH for Diabetes in Youth Study" @default.
- W2000366357 cites W1967033048 @default.
- W2000366357 cites W1997101648 @default.
- W2000366357 cites W2009802964 @default.
- W2000366357 cites W2017695531 @default.
- W2000366357 cites W2029812940 @default.
- W2000366357 cites W2036270966 @default.
- W2000366357 cites W2048952563 @default.
- W2000366357 cites W2050044633 @default.
- W2000366357 cites W2077599596 @default.
- W2000366357 cites W2087019248 @default.
- W2000366357 cites W2093212346 @default.
- W2000366357 cites W2094579373 @default.
- W2000366357 cites W2112947547 @default.
- W2000366357 cites W2139469679 @default.
- W2000366357 cites W2145477515 @default.
- W2000366357 cites W2148638284 @default.
- W2000366357 cites W2153255949 @default.
- W2000366357 cites W2157049076 @default.
- W2000366357 cites W2342004103 @default.
- W2000366357 cites W4213226519 @default.
- W2000366357 cites W4229611233 @default.
- W2000366357 cites W4242942625 @default.
- W2000366357 cites W4245934278 @default.
- W2000366357 cites W4247228698 @default.
- W2000366357 cites W4252027638 @default.
- W2000366357 doi "https://doi.org/10.1111/j.1399-5448.2007.00241.x" @default.
- W2000366357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18036060" @default.
- W2000366357 hasPublicationYear "2007" @default.
- W2000366357 type Work @default.
- W2000366357 sameAs 2000366357 @default.
- W2000366357 citedByCount "17" @default.
- W2000366357 countsByYear W20003663572012 @default.
- W2000366357 countsByYear W20003663572015 @default.
- W2000366357 countsByYear W20003663572016 @default.
- W2000366357 countsByYear W20003663572017 @default.
- W2000366357 countsByYear W20003663572020 @default.
- W2000366357 countsByYear W20003663572022 @default.
- W2000366357 countsByYear W20003663572023 @default.
- W2000366357 crossrefType "journal-article" @default.
- W2000366357 hasAuthorship W2000366357A5027771126 @default.
- W2000366357 hasAuthorship W2000366357A5031187973 @default.
- W2000366357 hasAuthorship W2000366357A5034609462 @default.
- W2000366357 hasAuthorship W2000366357A5035421263 @default.
- W2000366357 hasAuthorship W2000366357A5035584432 @default.
- W2000366357 hasAuthorship W2000366357A5037503691 @default.
- W2000366357 hasAuthorship W2000366357A5040740270 @default.
- W2000366357 hasAuthorship W2000366357A5089972335 @default.
- W2000366357 hasBestOaLocation W20003663571 @default.
- W2000366357 hasConcept C126322002 @default.
- W2000366357 hasConcept C134018914 @default.
- W2000366357 hasConcept C156957248 @default.
- W2000366357 hasConcept C2777180221 @default.
- W2000366357 hasConcept C2780221984 @default.
- W2000366357 hasConcept C2781179581 @default.
- W2000366357 hasConcept C2781232474 @default.
- W2000366357 hasConcept C44249647 @default.
- W2000366357 hasConcept C555293320 @default.
- W2000366357 hasConcept C71924100 @default.
- W2000366357 hasConceptScore W2000366357C126322002 @default.
- W2000366357 hasConceptScore W2000366357C134018914 @default.
- W2000366357 hasConceptScore W2000366357C156957248 @default.
- W2000366357 hasConceptScore W2000366357C2777180221 @default.
- W2000366357 hasConceptScore W2000366357C2780221984 @default.
- W2000366357 hasConceptScore W2000366357C2781179581 @default.
- W2000366357 hasConceptScore W2000366357C2781232474 @default.
- W2000366357 hasConceptScore W2000366357C44249647 @default.
- W2000366357 hasConceptScore W2000366357C555293320 @default.
- W2000366357 hasConceptScore W2000366357C71924100 @default.
- W2000366357 hasIssue "6" @default.
- W2000366357 hasLocation W20003663571 @default.
- W2000366357 hasLocation W20003663572 @default.
- W2000366357 hasOpenAccess W2000366357 @default.
- W2000366357 hasPrimaryLocation W20003663571 @default.
- W2000366357 hasRelatedWork W2020562735 @default.
- W2000366357 hasRelatedWork W2074686980 @default.
- W2000366357 hasRelatedWork W2076497798 @default.
- W2000366357 hasRelatedWork W2267179084 @default.
- W2000366357 hasRelatedWork W2394348704 @default.
- W2000366357 hasRelatedWork W2412321321 @default.
- W2000366357 hasRelatedWork W2886937026 @default.
- W2000366357 hasRelatedWork W3009186173 @default.
- W2000366357 hasRelatedWork W3138679912 @default.
- W2000366357 hasRelatedWork W2998554054 @default.
- W2000366357 hasVolume "8" @default.
- W2000366357 isParatext "false" @default.