FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000366627> ?p ?o ?g. }

• W2000366627 endingPage "2302" @default.
• W2000366627 startingPage "2292" @default.
• W2000366627 abstract "Common practice to evaluate the efficacy of any compound as drug is done in cell-based in vitro system followed by in vivo murine model prior to clinical trial in human. Cardiac glycosides are very effective to kill human cells, but not murine cells. In this report, we describe the comparative molecular mechanism of oleandrin, a cardiac glycoside action in human and murine cells. Treatment with oleandrin facilitated nuclear translocation of FKHR in human, but not murine cells by dephosphorylating Akt. It activated MAPK and JNK in human, but not in murine cells and also induced expression of FasL leads to apoptosis in human cells as detected by assaying caspases activation, PARP cleavage, nuclear fragmentation, and annexin staining. Oleandrin interacted with human plasma membrane as evaluated by HPLC, altered its fluidity as detected by DPH binding, inhibited Na+/K+-ATPase activity, and increased intracellular free Ca2+ level followed by calcineurin activity only in human, but not in murine cells. Results suggest that human plasma membrane might be different than murine, which interact with oleandrin that disturb Na+/K+-ATPase pump resulting in the calcification followed by induction of Ca2+-dependent cellular responses such as apoptosis." @default.
• W2000366627 created "2016-06-24" @default.
• W2000366627 creator A5031631094 @default.
• W2000366627 creator A5066205607 @default.
• W2000366627 creator A5074524164 @default.
• W2000366627 date "2007-03-01" @default.
• W2000366627 modified "2023-10-04" @default.
• W2000366627 title "Oleandrin induces apoptosis in human, but not in murine cells: Dephosphorylation of Akt, expression of FasL, and alteration of membrane fluidity" @default.
• W2000366627 cites W12631990 @default.
• W2000366627 cites W1498427877 @default.
• W2000366627 cites W1569503463 @default.
• W2000366627 cites W1642619880 @default.
• W2000366627 cites W1843209045 @default.
• W2000366627 cites W1964897058 @default.
• W2000366627 cites W1977210234 @default.
• W2000366627 cites W1985885348 @default.
• W2000366627 cites W1991163286 @default.
• W2000366627 cites W1993753373 @default.
• W2000366627 cites W1999242709 @default.
• W2000366627 cites W2006756719 @default.
• W2000366627 cites W2016185162 @default.
• W2000366627 cites W2018741186 @default.
• W2000366627 cites W2022977288 @default.
• W2000366627 cites W2039425889 @default.
• W2000366627 cites W2051884044 @default.
• W2000366627 cites W2065547075 @default.
• W2000366627 cites W2069034973 @default.
• W2000366627 cites W2070765025 @default.
• W2000366627 cites W2075270738 @default.
• W2000366627 cites W2110396329 @default.
• W2000366627 cites W2118870612 @default.
• W2000366627 cites W2120500844 @default.
• W2000366627 cites W2137035181 @default.
• W2000366627 cites W2140858827 @default.
• W2000366627 cites W2142887196 @default.
• W2000366627 cites W2154035441 @default.
• W2000366627 cites W2156433522 @default.
• W2000366627 cites W2172196619 @default.
• W2000366627 cites W4233116228 @default.
• W2000366627 doi "https://doi.org/10.1016/j.molimm.2006.11.009" @default.
• W2000366627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17173971" @default.
• W2000366627 hasPublicationYear "2007" @default.
• W2000366627 type Work @default.
• W2000366627 sameAs 2000366627 @default.
• W2000366627 citedByCount "51" @default.
• W2000366627 countsByYear W20003666272012 @default.
• W2000366627 countsByYear W20003666272013 @default.
• W2000366627 countsByYear W20003666272014 @default.
• W2000366627 countsByYear W20003666272015 @default.
• W2000366627 countsByYear W20003666272016 @default.
• W2000366627 countsByYear W20003666272017 @default.
• W2000366627 countsByYear W20003666272018 @default.
• W2000366627 countsByYear W20003666272020 @default.
• W2000366627 countsByYear W20003666272021 @default.
• W2000366627 countsByYear W20003666272022 @default.
• W2000366627 countsByYear W20003666272023 @default.
• W2000366627 crossrefType "journal-article" @default.
• W2000366627 hasAuthorship W2000366627A5031631094 @default.
• W2000366627 hasAuthorship W2000366627A5066205607 @default.
• W2000366627 hasAuthorship W2000366627A5074524164 @default.
• W2000366627 hasConcept C153911025 @default.
• W2000366627 hasConcept C179464577 @default.
• W2000366627 hasConcept C185592680 @default.
• W2000366627 hasConcept C190283241 @default.
• W2000366627 hasConcept C203014093 @default.
• W2000366627 hasConcept C2776090121 @default.
• W2000366627 hasConcept C31573885 @default.
• W2000366627 hasConcept C55493867 @default.
• W2000366627 hasConcept C66008609 @default.
• W2000366627 hasConcept C75217442 @default.
• W2000366627 hasConcept C86803240 @default.
• W2000366627 hasConcept C88634738 @default.
• W2000366627 hasConcept C8891405 @default.
• W2000366627 hasConcept C95444343 @default.
• W2000366627 hasConcept C98424977 @default.
• W2000366627 hasConceptScore W2000366627C153911025 @default.
• W2000366627 hasConceptScore W2000366627C179464577 @default.
• W2000366627 hasConceptScore W2000366627C185592680 @default.
• W2000366627 hasConceptScore W2000366627C190283241 @default.
• W2000366627 hasConceptScore W2000366627C203014093 @default.
• W2000366627 hasConceptScore W2000366627C2776090121 @default.
• W2000366627 hasConceptScore W2000366627C31573885 @default.
• W2000366627 hasConceptScore W2000366627C55493867 @default.
• W2000366627 hasConceptScore W2000366627C66008609 @default.
• W2000366627 hasConceptScore W2000366627C75217442 @default.
• W2000366627 hasConceptScore W2000366627C86803240 @default.
• W2000366627 hasConceptScore W2000366627C88634738 @default.
• W2000366627 hasConceptScore W2000366627C8891405 @default.
• W2000366627 hasConceptScore W2000366627C95444343 @default.
• W2000366627 hasConceptScore W2000366627C98424977 @default.
• W2000366627 hasIssue "9" @default.
• W2000366627 hasLocation W20003666271 @default.
• W2000366627 hasLocation W20003666272 @default.
• W2000366627 hasOpenAccess W2000366627 @default.
• W2000366627 hasPrimaryLocation W20003666271 @default.
• W2000366627 hasRelatedWork W1969539686 @default.
• W2000366627 hasRelatedWork W1984390541 @default.
• W2000366627 hasRelatedWork W2058477413 @default.

• next