FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000366854> ?p ?o ?g. }

• W2000366854 endingPage "1034" @default.
• W2000366854 startingPage "1029" @default.
• W2000366854 abstract "The retinoic acid receptor-related receptors (RORs) are members of the nuclear receptor (NR) superfamily of transcription factors. Several NRs are still characterized as orphan receptors because ligands have not yet been identified for these proteins. Here, we describe the identification of a synthetic RORα/RORγ ligand, SR1078. SR1078 modulates the conformation of RORγ in a biochemical assay and activates RORα and RORγ driven transcription. Furthermore, SR1078 stimulates expression of endogenous ROR target genes in HepG2 cells that express both RORα and RORγ. Pharmacokinetic studies indicate that SR1078 displays reasonable exposure following injection into mice, and consistent with SR1078 functioning as a RORα/RORγ agonist, expression of two ROR target genes, glucose-6-phosphatase and fibroblast growth factor 21, were stimulated in the liver. Thus, we have identified the first synthetic RORα/γ agonist, and this compound can be utilized as a chemical tool to probe the function of these receptors both in vitro and in vivo." @default.
• W2000366854 created "2016-06-24" @default.
• W2000366854 creator A5000139914 @default.
• W2000366854 creator A5006644159 @default.
• W2000366854 creator A5030278045 @default.
• W2000366854 creator A5041449809 @default.
• W2000366854 creator A5045681846 @default.
• W2000366854 creator A5065999911 @default.
• W2000366854 creator A5081275918 @default.
• W2000366854 creator A5089941593 @default.
• W2000366854 date "2010-08-30" @default.
• W2000366854 modified "2023-10-18" @default.
• W2000366854 title "Identification of SR1078, a Synthetic Agonist for the Orphan Nuclear Receptors RORα and RORγ" @default.
• W2000366854 cites W1572091120 @default.
• W2000366854 cites W1965546595 @default.
• W2000366854 cites W1969181250 @default.
• W2000366854 cites W1975191711 @default.
• W2000366854 cites W1976034245 @default.
• W2000366854 cites W2007172433 @default.
• W2000366854 cites W2010762097 @default.
• W2000366854 cites W2019796661 @default.
• W2000366854 cites W2030150229 @default.
• W2000366854 cites W2056045775 @default.
• W2000366854 cites W2073356061 @default.
• W2000366854 cites W2075321614 @default.
• W2000366854 cites W2089735989 @default.
• W2000366854 cites W2089756004 @default.
• W2000366854 cites W2091451666 @default.
• W2000366854 cites W2094566719 @default.
• W2000366854 cites W2096815093 @default.
• W2000366854 cites W2109041281 @default.
• W2000366854 cites W2119953207 @default.
• W2000366854 cites W2125624563 @default.
• W2000366854 cites W2142017607 @default.
• W2000366854 cites W2153673003 @default.
• W2000366854 doi "https://doi.org/10.1021/cb100223d" @default.
• W2000366854 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3003750" @default.
• W2000366854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20735016" @default.
• W2000366854 hasPublicationYear "2010" @default.
• W2000366854 type Work @default.
• W2000366854 sameAs 2000366854 @default.
• W2000366854 citedByCount "132" @default.
• W2000366854 countsByYear W20003668542012 @default.
• W2000366854 countsByYear W20003668542013 @default.
• W2000366854 countsByYear W20003668542014 @default.
• W2000366854 countsByYear W20003668542015 @default.
• W2000366854 countsByYear W20003668542016 @default.
• W2000366854 countsByYear W20003668542017 @default.
• W2000366854 countsByYear W20003668542018 @default.
• W2000366854 countsByYear W20003668542019 @default.
• W2000366854 countsByYear W20003668542020 @default.
• W2000366854 countsByYear W20003668542021 @default.
• W2000366854 countsByYear W20003668542022 @default.
• W2000366854 countsByYear W20003668542023 @default.
• W2000366854 crossrefType "journal-article" @default.
• W2000366854 hasAuthorship W2000366854A5000139914 @default.
• W2000366854 hasAuthorship W2000366854A5006644159 @default.
• W2000366854 hasAuthorship W2000366854A5030278045 @default.
• W2000366854 hasAuthorship W2000366854A5041449809 @default.
• W2000366854 hasAuthorship W2000366854A5045681846 @default.
• W2000366854 hasAuthorship W2000366854A5065999911 @default.
• W2000366854 hasAuthorship W2000366854A5081275918 @default.
• W2000366854 hasAuthorship W2000366854A5089941593 @default.
• W2000366854 hasBestOaLocation W20003668542 @default.
• W2000366854 hasConcept C104317684 @default.
• W2000366854 hasConcept C170493617 @default.
• W2000366854 hasConcept C185592680 @default.
• W2000366854 hasConcept C23525593 @default.
• W2000366854 hasConcept C2778938600 @default.
• W2000366854 hasConcept C2779161069 @default.
• W2000366854 hasConcept C2781121885 @default.
• W2000366854 hasConcept C55493867 @default.
• W2000366854 hasConcept C63932345 @default.
• W2000366854 hasConcept C74737994 @default.
• W2000366854 hasConcept C86339819 @default.
• W2000366854 hasConcept C86803240 @default.
• W2000366854 hasConcept C95444343 @default.
• W2000366854 hasConceptScore W2000366854C104317684 @default.
• W2000366854 hasConceptScore W2000366854C170493617 @default.
• W2000366854 hasConceptScore W2000366854C185592680 @default.
• W2000366854 hasConceptScore W2000366854C23525593 @default.
• W2000366854 hasConceptScore W2000366854C2778938600 @default.
• W2000366854 hasConceptScore W2000366854C2779161069 @default.
• W2000366854 hasConceptScore W2000366854C2781121885 @default.
• W2000366854 hasConceptScore W2000366854C55493867 @default.
• W2000366854 hasConceptScore W2000366854C63932345 @default.
• W2000366854 hasConceptScore W2000366854C74737994 @default.
• W2000366854 hasConceptScore W2000366854C86339819 @default.
• W2000366854 hasConceptScore W2000366854C86803240 @default.
• W2000366854 hasConceptScore W2000366854C95444343 @default.
• W2000366854 hasIssue "11" @default.
• W2000366854 hasLocation W20003668541 @default.
• W2000366854 hasLocation W20003668542 @default.
• W2000366854 hasLocation W20003668543 @default.
• W2000366854 hasLocation W20003668544 @default.
• W2000366854 hasOpenAccess W2000366854 @default.
• W2000366854 hasPrimaryLocation W20003668541 @default.
• W2000366854 hasRelatedWork W1980017607 @default.

• next