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- W2000367271 abstract "Transcriptional networks are constituted by a collection of building blocks known as network motifs. Why do motifs appear? An adaptive model of motif emergence was recently questioned in favor of neutralist scenarios. Here, we provide a new picture of motif assembly in Escherichia coli which partially clarifies these contrasting explanations. This is based on characterizing the linkage between motifs and sensing or response specificity of their constituent transcriptional factors (TFs). We find that sensing specificity influences the distribution of autoregulation, while the tendency of a TF to establish feed-forward loops (FFLs) depends on response specificity, i.e., regulon size. Analysis of the latter pattern reveals that coregulation between large regulon-size TFs is common under a network neutral model, leading to the assembly of a great number of FFLs and bifans. In addition, neutral exclusive regulation also leads to a collection of single input modules -the fourth basic motif. On the whole, and even under the conservative neutralist scenario considered, a substantial group of regulatory structures revealed adaptive. These structures visibly function as fully-fledged working units." @default.
- W2000367271 created "2016-06-24" @default.
- W2000367271 creator A5017749589 @default.
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- W2000367271 date "2008-11-06" @default.
- W2000367271 modified "2023-09-25" @default.
- W2000367271 title "What Determines the Assembly of Transcriptional Network Motifs in Escherichia coli?" @default.
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- W2000367271 doi "https://doi.org/10.1371/journal.pone.0003657" @default.
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