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- W2000368393 abstract "The effects of intravenous immunoglobulins (IVIg) on anti-GM1 IgM titer and function, classical complement pathway activity, and antibody–complement interaction were investigated in 62 patients with multifocal motor neuropathy (MMN). In vitro, IVIg decreased complement deposition by anti-GM1 IgM antibodies. First IVIg treatment (2 g/kg) decreased C1q and C4 concentrations and classical pathway activity in serum. In sera from patients receiving IVIg maintenance therapy (0.4 g/kg) C4 concentrations and classical pathway activity were generally lower at higher IgG concentrations. The beneficial effects of IVIg in MMN may be explained by reduced antibody-mediated complement deposition in nerves amplified by a systemically attenuated classical pathway." @default.
- W2000368393 created "2016-06-24" @default.
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- W2000368393 date "2010-12-15" @default.
- W2000368393 modified "2023-10-04" @default.
- W2000368393 title "IVIg inhibits classical pathway activity and anti-GM1 IgM-mediated complement deposition in MMN" @default.
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- W2000368393 doi "https://doi.org/10.1016/j.jneuroim.2010.08.023" @default.
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