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• W2000369736 abstract "Mutations in the isocitrate dehydrogenase (IDH) genes are frequently found in gliomas and in a fraction of acute myeloid leukemia patients. This results in the production of an oncometabolite, 2-hydroxyglutarate (2-HG). Glioma patients harboring IDH mutations have a longer survival than their wild-type counterparts. 2-HG has been detected noninvasively in gliomas with IDH mutations using magnetic resonance spectroscopy (MRS), suggesting its potential clinical relevance for identifying glioma subtypes with better prognosis. In this paper, the recent developments in the MRS detection of the 2-HG in gliomas are reviewed, including the therapeutic potentials and translational values." @default.
• W2000369736 created "2016-06-24" @default.
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• W2000369736 date "2013-04-01" @default.
• W2000369736 modified "2023-10-05" @default.
• W2000369736 title "2-Hydroxyglutarate as a Magnetic Resonance Biomarker for Glioma Subtyping" @default.
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• W2000369736 doi "https://doi.org/10.1593/tlo.12424" @default.
• W2000369736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3610550" @default.
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