FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000369867> ?p ?o ?g. }

• W2000369867 abstract "Abstract Background HIV-1 infection affects malaria humeral immunity during pregnancy, but data for non-pregnant adults are lacking. This study reports the impact of HIV-1 infection and other variables on the level of malaria humeral immunity in adults with clinical malaria and whether humeral immune suppression was a risk factor for treatment failure. Methods Sera of 224 HIV-1 infected and 115 uninfected adults were compared for IgG to merozoite antigens AMA-1 and MSP2 (3D7 and FC27 types) determined by ELISA, and for IgG to the Variant Surface Antigens (VSA) of three different parasite line E8B, A4 and HCD6 determined by flow cytometry. Results Compared to HIV-1 uninfected adults, AMA-1 IgG was lower in HIV-1 infected ( P = 0.02) and associated with low CD4 count AMA-1 IgG ( P = 0.003). Low IgG to all three merozoite antigens was associated with less anemia ( P = 0.03). High parasite load was associated with low MSP2 IgG 3D7 and FC27 types ( P = 0.02 and P = 0.08). Antibody levels to VSA did not differ between HIV-1 infected and uninfected adults. However, low VSA IgGs were associated with high parasite load ( P ≤ 0.002 for each parasite line) and with treatment failure ( P ≤ 0.04 for each parasite line). Conclusion HIV-1 affects humeral responses to AMA-1, but seems to marginally or not affect humeral responses to other merozoite antigens and VSAs. The latter were important for controlling parasite density and predict treatment outcome." @default.
• W2000369867 created "2016-06-24" @default.
• W2000369867 creator A5009095999 @default.
• W2000369867 creator A5012913548 @default.
• W2000369867 creator A5033754121 @default.
• W2000369867 creator A5049265849 @default.
• W2000369867 creator A5049862713 @default.
• W2000369867 creator A5068576041 @default.
• W2000369867 creator A5085898750 @default.
• W2000369867 date "2009-11-18" @default.
• W2000369867 modified "2023-10-14" @default.
• W2000369867 title "The relationship of Plasmodium falciparum humeral immunity with HIV-1 immunosuppression and treatment efficacy in Zambia" @default.
• W2000369867 cites W1517373353 @default.
• W2000369867 cites W1838069648 @default.
• W2000369867 cites W1967304374 @default.
• W2000369867 cites W1970914759 @default.
• W2000369867 cites W1972623575 @default.
• W2000369867 cites W1973200069 @default.
• W2000369867 cites W1974340844 @default.
• W2000369867 cites W1976640605 @default.
• W2000369867 cites W1977648288 @default.
• W2000369867 cites W1986159395 @default.
• W2000369867 cites W1996925423 @default.
• W2000369867 cites W1998683359 @default.
• W2000369867 cites W1998752052 @default.
• W2000369867 cites W2005470158 @default.
• W2000369867 cites W2036660987 @default.
• W2000369867 cites W2039227742 @default.
• W2000369867 cites W2039900986 @default.
• W2000369867 cites W2042709462 @default.
• W2000369867 cites W2045151339 @default.
• W2000369867 cites W2056114294 @default.
• W2000369867 cites W2058714706 @default.
• W2000369867 cites W2061015904 @default.
• W2000369867 cites W2063010600 @default.
• W2000369867 cites W2085433980 @default.
• W2000369867 cites W2086691655 @default.
• W2000369867 cites W2103063011 @default.
• W2000369867 cites W2110540861 @default.
• W2000369867 cites W2111780819 @default.
• W2000369867 cites W2113340504 @default.
• W2000369867 cites W2115445412 @default.
• W2000369867 cites W2129816308 @default.
• W2000369867 cites W2141139703 @default.
• W2000369867 cites W2146018615 @default.
• W2000369867 cites W2146361457 @default.
• W2000369867 cites W2149315411 @default.
• W2000369867 cites W2150420464 @default.
• W2000369867 cites W2159669315 @default.
• W2000369867 cites W2168782257 @default.
• W2000369867 cites W2169012335 @default.
• W2000369867 cites W2219211024 @default.
• W2000369867 doi "https://doi.org/10.1186/1475-2875-8-258" @default.
• W2000369867 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2784793" @default.
• W2000369867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19922664" @default.
• W2000369867 hasPublicationYear "2009" @default.
• W2000369867 type Work @default.
• W2000369867 sameAs 2000369867 @default.
• W2000369867 citedByCount "20" @default.
• W2000369867 countsByYear W20003698672012 @default.
• W2000369867 countsByYear W20003698672013 @default.
• W2000369867 countsByYear W20003698672014 @default.
• W2000369867 countsByYear W20003698672015 @default.
• W2000369867 countsByYear W20003698672016 @default.
• W2000369867 countsByYear W20003698672017 @default.
• W2000369867 crossrefType "journal-article" @default.
• W2000369867 hasAuthorship W2000369867A5009095999 @default.
• W2000369867 hasAuthorship W2000369867A5012913548 @default.
• W2000369867 hasAuthorship W2000369867A5033754121 @default.
• W2000369867 hasAuthorship W2000369867A5049265849 @default.
• W2000369867 hasAuthorship W2000369867A5049862713 @default.
• W2000369867 hasAuthorship W2000369867A5068576041 @default.
• W2000369867 hasAuthorship W2000369867A5085898750 @default.
• W2000369867 hasBestOaLocation W20003698671 @default.
• W2000369867 hasConcept C136764020 @default.
• W2000369867 hasConcept C147483822 @default.
• W2000369867 hasConcept C159047783 @default.
• W2000369867 hasConcept C159654299 @default.
• W2000369867 hasConcept C203014093 @default.
• W2000369867 hasConcept C2775993617 @default.
• W2000369867 hasConcept C2778048844 @default.
• W2000369867 hasConcept C2778371730 @default.
• W2000369867 hasConcept C2779341262 @default.
• W2000369867 hasConcept C2780252810 @default.
• W2000369867 hasConcept C41008148 @default.
• W2000369867 hasConcept C71924100 @default.
• W2000369867 hasConcept C71928629 @default.
• W2000369867 hasConcept C86803240 @default.
• W2000369867 hasConcept C8891405 @default.
• W2000369867 hasConceptScore W2000369867C136764020 @default.
• W2000369867 hasConceptScore W2000369867C147483822 @default.
• W2000369867 hasConceptScore W2000369867C159047783 @default.
• W2000369867 hasConceptScore W2000369867C159654299 @default.
• W2000369867 hasConceptScore W2000369867C203014093 @default.
• W2000369867 hasConceptScore W2000369867C2775993617 @default.
• W2000369867 hasConceptScore W2000369867C2778048844 @default.
• W2000369867 hasConceptScore W2000369867C2778371730 @default.
• W2000369867 hasConceptScore W2000369867C2779341262 @default.
• W2000369867 hasConceptScore W2000369867C2780252810 @default.
• W2000369867 hasConceptScore W2000369867C41008148 @default.

• next