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• W2000371106 endingPage "1392" @default.
• W2000371106 startingPage "1386" @default.
• W2000371106 abstract "Nuclear oncogene products have the potential to induce alterations in gene regulation leading to the genesis of cancer. The biochemical mechanisms by which nuclear oncoproteins act remain unknown. Recently, an oncogene, v-jun, was found to share homology with the DNA binding domain of a yeast transcription factor, GCN4. Furthermore, GCN4 and the phorbol ester-inducible enhancer binding protein, AP-1, recognize very similar DNA sequences. The human proto-oncogene c-jun has now been isolated, and the deduced amino acid sequence indicates more than 80 percent identity with v-jun. Expression of cloned c-jun in bacteria produced a protein with sequence-specific DNA binding properties identical to AP-1. Antibodies raised against two distinct peptides derived from v-jun reacted specifically with human AP-1. In addition, partial amino acid sequence of purified AP-1 revealed tryptic peptides in common with the c-jun protein. The structural and functional similarities between the c-jun product and the enhancer binding protein suggest that AP-1 may be encoded by c-jun. These findings demonstrate that the proto-oncogene product of c-jun interacts directly with specific target DNA sequences to regulate gene expression, and therefore it may now be possible to identify genes under the control of c-jun that affect cell growth and neoplasia." @default.
• W2000371106 created "2016-06-24" @default.
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• W2000371106 date "1987-12-04" @default.
• W2000371106 modified "2023-10-10" @default.
• W2000371106 title "Human Proto-Oncogene c- <i>jun</i> Encodes a DNA Binding Protein with Structural and Functional Properties pf Transcription Factor AP-1" @default.
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• W2000371106 doi "https://doi.org/10.1126/science.2825349" @default.
• W2000371106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2825349" @default.
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