FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000371434> ?p ?o ?g. }

• W2000371434 endingPage "243" @default.
• W2000371434 startingPage "237" @default.
• W2000371434 abstract "The results from our laboratory summarized in this review support the importance of endotoxin release from the Gram-negative microbe as a requirement for the full manifestation of the biological activity of the lipopolysaccharide (LPS) macromolecule. They further suggest that LPS is the most important bacterial component released from Gram-negative microbes treated in vitro with cell-wall active antibiotics in terms of biological activity. The use of several experimental mouse models of infection confirm that mice treated with the reversible hepatotoxin, D-galactosamine, are sensitive to both endotoxin lethality and to infection with Gram-negative microbes. Infected LPS-sensitive animals can be protected if they are treated with antibiotics, but the degree of protection (e.g. 5-10-fold) is significantly less than that observed when infection-sensitive but LPS-insensitive mice are similarly treated (500-fold protection). Additional levels of protection in infected, antibiotic-treated mice can be observed with antiendotoxin agents (e.g. polymyxin B-dextran, monoclonal antibody). Finally, antibiotics with equivalent minimal inhibitory concentrations for Escherichia coli, but differing in their mode of action and endotoxin releasing potential in vitro, also differ in their protective efficacy in vivo to reduce mortality in infected animals. Collectively, these data provide evidence to support a role for microbe-derived endotoxin, released from the microbial surface following treatment with cell-wall active antibiotics, in the pathogenesis of experimental Gram-negative sepsis." @default.
• W2000371434 created "2016-06-24" @default.
• W2000371434 creator A5009196727 @default.
• W2000371434 creator A5011330394 @default.
• W2000371434 creator A5021491222 @default.
• W2000371434 creator A5070276558 @default.
• W2000371434 date "1996-06-01" @default.
• W2000371434 modified "2023-09-27" @default.
• W2000371434 title "Contribution of soluble endotoxin released from Gram-negative bacteria by antibiotics to the pathogenesis of experimental sepsis in mice" @default.
• W2000371434 cites W1894549605 @default.
• W2000371434 cites W1994915575 @default.
• W2000371434 cites W2021370090 @default.
• W2000371434 cites W2092289140 @default.
• W2000371434 cites W2098392324 @default.
• W2000371434 cites W2104661657 @default.
• W2000371434 cites W2112467006 @default.
• W2000371434 cites W2122974660 @default.
• W2000371434 cites W2128144326 @default.
• W2000371434 cites W2139793660 @default.
• W2000371434 cites W2145509829 @default.
• W2000371434 cites W2165781405 @default.
• W2000371434 cites W2171680926 @default.
• W2000371434 cites W2616307005 @default.
• W2000371434 cites W2768146862 @default.
• W2000371434 doi "https://doi.org/10.1177/096805199600300309" @default.
• W2000371434 hasPublicationYear "1996" @default.
• W2000371434 type Work @default.
• W2000371434 sameAs 2000371434 @default.
• W2000371434 citedByCount "18" @default.
• W2000371434 countsByYear W20003714342015 @default.
• W2000371434 countsByYear W20003714342020 @default.
• W2000371434 crossrefType "journal-article" @default.
• W2000371434 hasAuthorship W2000371434A5009196727 @default.
• W2000371434 hasAuthorship W2000371434A5011330394 @default.
• W2000371434 hasAuthorship W2000371434A5021491222 @default.
• W2000371434 hasAuthorship W2000371434A5070276558 @default.
• W2000371434 hasConcept C104317684 @default.
• W2000371434 hasConcept C149971331 @default.
• W2000371434 hasConcept C178790620 @default.
• W2000371434 hasConcept C185592680 @default.
• W2000371434 hasConcept C202751555 @default.
• W2000371434 hasConcept C203014093 @default.
• W2000371434 hasConcept C20379349 @default.
• W2000371434 hasConcept C2776051709 @default.
• W2000371434 hasConcept C2778384902 @default.
• W2000371434 hasConcept C2778754761 @default.
• W2000371434 hasConcept C29730261 @default.
• W2000371434 hasConcept C33070731 @default.
• W2000371434 hasConcept C501593827 @default.
• W2000371434 hasConcept C523546767 @default.
• W2000371434 hasConcept C54355233 @default.
• W2000371434 hasConcept C547475151 @default.
• W2000371434 hasConcept C55493867 @default.
• W2000371434 hasConcept C86803240 @default.
• W2000371434 hasConcept C89423630 @default.
• W2000371434 hasConceptScore W2000371434C104317684 @default.
• W2000371434 hasConceptScore W2000371434C149971331 @default.
• W2000371434 hasConceptScore W2000371434C178790620 @default.
• W2000371434 hasConceptScore W2000371434C185592680 @default.
• W2000371434 hasConceptScore W2000371434C202751555 @default.
• W2000371434 hasConceptScore W2000371434C203014093 @default.
• W2000371434 hasConceptScore W2000371434C20379349 @default.
• W2000371434 hasConceptScore W2000371434C2776051709 @default.
• W2000371434 hasConceptScore W2000371434C2778384902 @default.
• W2000371434 hasConceptScore W2000371434C2778754761 @default.
• W2000371434 hasConceptScore W2000371434C29730261 @default.
• W2000371434 hasConceptScore W2000371434C33070731 @default.
• W2000371434 hasConceptScore W2000371434C501593827 @default.
• W2000371434 hasConceptScore W2000371434C523546767 @default.
• W2000371434 hasConceptScore W2000371434C54355233 @default.
• W2000371434 hasConceptScore W2000371434C547475151 @default.
• W2000371434 hasConceptScore W2000371434C55493867 @default.
• W2000371434 hasConceptScore W2000371434C86803240 @default.
• W2000371434 hasConceptScore W2000371434C89423630 @default.
• W2000371434 hasIssue "3" @default.
• W2000371434 hasLocation W20003714341 @default.
• W2000371434 hasOpenAccess W2000371434 @default.
• W2000371434 hasPrimaryLocation W20003714341 @default.
• W2000371434 hasRelatedWork W1701903288 @default.
• W2000371434 hasRelatedWork W1964073630 @default.
• W2000371434 hasRelatedWork W1998248458 @default.
• W2000371434 hasRelatedWork W2004648073 @default.
• W2000371434 hasRelatedWork W2005137875 @default.
• W2000371434 hasRelatedWork W2065259989 @default.
• W2000371434 hasRelatedWork W2092289140 @default.
• W2000371434 hasRelatedWork W2093424527 @default.
• W2000371434 hasRelatedWork W2104661657 @default.
• W2000371434 hasRelatedWork W2109701048 @default.
• W2000371434 hasRelatedWork W2122974660 @default.
• W2000371434 hasRelatedWork W2156361044 @default.
• W2000371434 hasRelatedWork W2157245433 @default.
• W2000371434 hasRelatedWork W2164697563 @default.
• W2000371434 hasRelatedWork W2168846400 @default.
• W2000371434 hasRelatedWork W2171680926 @default.
• W2000371434 hasRelatedWork W2224410746 @default.
• W2000371434 hasRelatedWork W2335479186 @default.
• W2000371434 hasRelatedWork W3108161051 @default.
• W2000371434 hasRelatedWork W2434715143 @default.

• next