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• W2000371661 abstract "Lipin family proteins are emerging as crucial regulators of lipid metabolism. In triglyceride synthesis, lipins act as lipid phosphatase enzymes at the endoplasmic reticular membrane, catalyzing the dephosphorylation of phosphatidic acid to form diacylglycerol, which is the penultimate step in this process. However, lipin proteins are not integral membrane proteins, and can rapidly translocate within the cell. In fact, emerging evidence suggests that lipins also play crucial roles in the nucleus as transcriptional regulatory proteins. Thus, lipins are poised to regulate cellular lipid metabolism at multiple regulatory nodal points. This review summarizes the history of lipin proteins, and discusses the current state of our understanding of lipin biology. Lipin family proteins are emerging as crucial regulators of lipid metabolism. In triglyceride synthesis, lipins act as lipid phosphatase enzymes at the endoplasmic reticular membrane, catalyzing the dephosphorylation of phosphatidic acid to form diacylglycerol, which is the penultimate step in this process. However, lipin proteins are not integral membrane proteins, and can rapidly translocate within the cell. In fact, emerging evidence suggests that lipins also play crucial roles in the nucleus as transcriptional regulatory proteins. Thus, lipins are poised to regulate cellular lipid metabolism at multiple regulatory nodal points. This review summarizes the history of lipin proteins, and discusses the current state of our understanding of lipin biology." @default.
• W2000371661 created "2016-06-24" @default.
• W2000371661 creator A5080986969 @default.
• W2000371661 creator A5090313762 @default.
• W2000371661 date "2011-06-01" @default.
• W2000371661 modified "2023-10-02" @default.
• W2000371661 title "Dual function lipin proteins and glycerolipid metabolism" @default.
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• W2000371661 doi "https://doi.org/10.1016/j.tem.2011.02.006" @default.
• W2000371661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3118913" @default.
• W2000371661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21470873" @default.
• W2000371661 hasPublicationYear "2011" @default.
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