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- W2000371703 abstract "To assess the effects of pravastatin on lipoprotein levels and composition in patients with type 2 diabetes mellitus and hypercholesterolemia. The role of pravastatin in glucose control also was assessed. Several factors, including abnormalities of lipoprotein composition, may contribute to the increased risk of coronary heart disease in diabetes mellitus. Patients with type 2 diabetes mellitus of at least 3 years' duration entered the study at the 4-week run-in period, during which they received a standard diet. For the remaining 18 weeks of the study, they received pravastatin 20 mg/d. In 51 patients, pravastatin decreased total cholesterol concentrations (289 ± 40 to 227 ± 37) (P < 0.001), due mainly to a 29% decrease in low-density lipoprotein (LDL) cholesterol levels (P < 0.001). A significant decrease (12%–14%) was observed in triglycerides, whereas high-density lipoprotein cholesterol tended to increase. Apolipoprotein (apo) B decreased significantly (24%), while apo A-I and lipoprotein (a) concentrations did not change. Lipids decreased in apo B-containing particles with the reduction of triglycerides in very low-density lipoprotein (VLDL) and LDL and of cholesteryl esters (CEs) in LDL reaching significance. The triglyceride/CE core lipid ratio increased in VLDL (7.2 ± 2.2 vs 8.3 ± 2.2) (P < 0.05) and LDL (0.29 ± 0.07 vs 0.36 ± 0.09) (P < 0.05). There was no effect on glucose control. In patients with type 2 diabetes mellitus and hypercholesterolemia, pravastatin improved the lipid profile and the atherogenic potential associated with abnormal lipoprotein composition." @default.
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- W2000371703 date "2000-02-01" @default.
- W2000371703 modified "2023-09-26" @default.
- W2000371703 title "Effects of pravastatin treatment on lipoprotein levels and composition in patients with type 2 diabetes mellitus and hypercholesterolemia" @default.
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- W2000371703 doi "https://doi.org/10.1016/s0011-393x(00)88533-1" @default.
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