Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000372617> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2000372617 endingPage "234" @default.
- W2000372617 startingPage "230" @default.
- W2000372617 abstract "Relationships between the kinetic properties of AMPA receptors and the decay phase of fast excitatory transmission were investigated using modulatory drugs. The benzothiadiazide compound cyclothiazide blocked receptor desensitization in patches excised from hippocampus but had only a weak influence on receptor deactivation, i.e., on the decay of responses produced by a 1-ms pulse of glutamate. The ampakine drug CX516 (BDP-12) produced an opposite pattern of effects: a fourfold slowing of deactivation with little change in desensitization. A structurally related drug (CX554 or BDP-20) had prominent effects on both desensitization and deactivation. The halfwidth of field EPSPs measured in the CA1 region of hippocampal slices increased 50-100% in the presence of CX516 or CX554 but by less than 15% at concentrations of cyclothiazide that fully blocked desensitization in patch experiments. These results indicate that receptor deactivation plays a substantially greater role than receptor desensitization in determining the duration of synaptic responses." @default.
- W2000372617 created "2016-06-24" @default.
- W2000372617 creator A5004106201 @default.
- W2000372617 creator A5074348666 @default.
- W2000372617 date "1998-07-01" @default.
- W2000372617 modified "2023-10-13" @default.
- W2000372617 title "The waveform of synaptic transmission at hippocampal synapses is not determined by AMPA receptor desensitization" @default.
- W2000372617 cites W1636225847 @default.
- W2000372617 cites W1968097213 @default.
- W2000372617 cites W1980555336 @default.
- W2000372617 cites W1993319593 @default.
- W2000372617 cites W1995455732 @default.
- W2000372617 cites W2006046465 @default.
- W2000372617 cites W2007098578 @default.
- W2000372617 cites W2014039492 @default.
- W2000372617 cites W2014684062 @default.
- W2000372617 cites W2015472050 @default.
- W2000372617 cites W2016288186 @default.
- W2000372617 cites W2016415553 @default.
- W2000372617 cites W2027438525 @default.
- W2000372617 cites W2031843068 @default.
- W2000372617 cites W2032458901 @default.
- W2000372617 cites W2037373491 @default.
- W2000372617 cites W2045171292 @default.
- W2000372617 cites W2052033857 @default.
- W2000372617 cites W2063261415 @default.
- W2000372617 cites W2063792561 @default.
- W2000372617 cites W2086215179 @default.
- W2000372617 cites W2088880312 @default.
- W2000372617 cites W2128806021 @default.
- W2000372617 cites W2128904157 @default.
- W2000372617 cites W2302991284 @default.
- W2000372617 doi "https://doi.org/10.1016/s0006-8993(98)00446-6" @default.
- W2000372617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9675293" @default.
- W2000372617 hasPublicationYear "1998" @default.
- W2000372617 type Work @default.
- W2000372617 sameAs 2000372617 @default.
- W2000372617 citedByCount "48" @default.
- W2000372617 countsByYear W20003726172013 @default.
- W2000372617 countsByYear W20003726172014 @default.
- W2000372617 countsByYear W20003726172015 @default.
- W2000372617 countsByYear W20003726172019 @default.
- W2000372617 crossrefType "journal-article" @default.
- W2000372617 hasAuthorship W2000372617A5004106201 @default.
- W2000372617 hasAuthorship W2000372617A5074348666 @default.
- W2000372617 hasConcept C112592302 @default.
- W2000372617 hasConcept C12554922 @default.
- W2000372617 hasConcept C148762608 @default.
- W2000372617 hasConcept C160268369 @default.
- W2000372617 hasConcept C169760540 @default.
- W2000372617 hasConcept C170493617 @default.
- W2000372617 hasConcept C185592680 @default.
- W2000372617 hasConcept C200170125 @default.
- W2000372617 hasConcept C2779779143 @default.
- W2000372617 hasConcept C55493867 @default.
- W2000372617 hasConcept C61174792 @default.
- W2000372617 hasConcept C67018056 @default.
- W2000372617 hasConcept C86803240 @default.
- W2000372617 hasConcept C98274493 @default.
- W2000372617 hasConceptScore W2000372617C112592302 @default.
- W2000372617 hasConceptScore W2000372617C12554922 @default.
- W2000372617 hasConceptScore W2000372617C148762608 @default.
- W2000372617 hasConceptScore W2000372617C160268369 @default.
- W2000372617 hasConceptScore W2000372617C169760540 @default.
- W2000372617 hasConceptScore W2000372617C170493617 @default.
- W2000372617 hasConceptScore W2000372617C185592680 @default.
- W2000372617 hasConceptScore W2000372617C200170125 @default.
- W2000372617 hasConceptScore W2000372617C2779779143 @default.
- W2000372617 hasConceptScore W2000372617C55493867 @default.
- W2000372617 hasConceptScore W2000372617C61174792 @default.
- W2000372617 hasConceptScore W2000372617C67018056 @default.
- W2000372617 hasConceptScore W2000372617C86803240 @default.
- W2000372617 hasConceptScore W2000372617C98274493 @default.
- W2000372617 hasIssue "2" @default.
- W2000372617 hasLocation W20003726171 @default.
- W2000372617 hasLocation W20003726172 @default.
- W2000372617 hasOpenAccess W2000372617 @default.
- W2000372617 hasPrimaryLocation W20003726171 @default.
- W2000372617 hasRelatedWork W1972972710 @default.
- W2000372617 hasRelatedWork W2003914443 @default.
- W2000372617 hasRelatedWork W2021473125 @default.
- W2000372617 hasRelatedWork W2051973933 @default.
- W2000372617 hasRelatedWork W2076799937 @default.
- W2000372617 hasRelatedWork W2752655557 @default.
- W2000372617 hasRelatedWork W2990848504 @default.
- W2000372617 hasRelatedWork W3102980008 @default.
- W2000372617 hasRelatedWork W3159599675 @default.
- W2000372617 hasRelatedWork W2186807311 @default.
- W2000372617 hasVolume "799" @default.
- W2000372617 isParatext "false" @default.
- W2000372617 isRetracted "false" @default.
- W2000372617 magId "2000372617" @default.
- W2000372617 workType "article" @default.