Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000373300> ?p ?o ?g. }
- W2000373300 endingPage "147" @default.
- W2000373300 startingPage "141" @default.
- W2000373300 abstract "Lysine is a limiting essential amino acid in cereals, a major food source for humans and animals. Although cereals can synthesize lysine from aspartate, the pathway is feedback regulated in a manner that restricts lysine accumulation. Another step that restricts lysine accumulation in seeds is the saccharopine pathway for lysine catabolism. This pathway converts lysine to α-aminoadipic-δ-semialdehyde (AASA) by the bifunctional enzyme lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH). Then, AASA is converted to aminoadipic acid (AAA) by α-aminoadipic-δ-semialdehyde dehydrogenase (AASADH). The downregulation of LKR/SDH in seeds results in the overaccumulation of free lysine to levels that meet human nutritional requirements. However, the saccharopine pathway is also involved in stress response in plants, animals, and bacteria. In these organisms, the gene encoding LKR/SDH is upregulated under osmotic, salt, and oxidative stress conditions. The role of the saccharopine pathway in stress response is not well understood, but the overexpression of AASADH results in stress-tolerant plants and animal cells. The saccharopine pathway may thus act either by producing osmolytes, such as pipecolic acid and proline, or by signaling compounds that regulate stress-response genes. In this review, we discuss the potential use of the saccharopine pathway to engineer nutritional-rich and stress-tolerant crops." @default.
- W2000373300 created "2016-06-24" @default.
- W2000373300 creator A5042669780 @default.
- W2000373300 creator A5055294011 @default.
- W2000373300 date "2012-08-02" @default.
- W2000373300 modified "2023-10-11" @default.
- W2000373300 title "Nutritional‐rich and stress‐tolerant crops by saccharopine pathway manipulation" @default.
- W2000373300 cites W1578749261 @default.
- W2000373300 cites W1776227482 @default.
- W2000373300 cites W1963839313 @default.
- W2000373300 cites W1980517307 @default.
- W2000373300 cites W1984085308 @default.
- W2000373300 cites W1989711390 @default.
- W2000373300 cites W1990528372 @default.
- W2000373300 cites W1994612294 @default.
- W2000373300 cites W1996484845 @default.
- W2000373300 cites W1998221192 @default.
- W2000373300 cites W1999042349 @default.
- W2000373300 cites W1999371357 @default.
- W2000373300 cites W2007601852 @default.
- W2000373300 cites W2011647341 @default.
- W2000373300 cites W2013859310 @default.
- W2000373300 cites W2027211358 @default.
- W2000373300 cites W2027534142 @default.
- W2000373300 cites W2035347038 @default.
- W2000373300 cites W2038920204 @default.
- W2000373300 cites W2046689663 @default.
- W2000373300 cites W2066720918 @default.
- W2000373300 cites W2070329863 @default.
- W2000373300 cites W2081773790 @default.
- W2000373300 cites W2083902001 @default.
- W2000373300 cites W2089759190 @default.
- W2000373300 cites W2090077018 @default.
- W2000373300 cites W2090751865 @default.
- W2000373300 cites W2095926487 @default.
- W2000373300 cites W2097120984 @default.
- W2000373300 cites W2102275335 @default.
- W2000373300 cites W2103208135 @default.
- W2000373300 cites W2105883309 @default.
- W2000373300 cites W2110349321 @default.
- W2000373300 cites W2117206586 @default.
- W2000373300 cites W2117547035 @default.
- W2000373300 cites W2119899271 @default.
- W2000373300 cites W2124008042 @default.
- W2000373300 cites W2135114355 @default.
- W2000373300 cites W2140217989 @default.
- W2000373300 cites W2140585622 @default.
- W2000373300 cites W2144063867 @default.
- W2000373300 cites W2144952391 @default.
- W2000373300 cites W2145908472 @default.
- W2000373300 cites W2163386700 @default.
- W2000373300 cites W2170529632 @default.
- W2000373300 cites W4233484459 @default.
- W2000373300 cites W52066198 @default.
- W2000373300 doi "https://doi.org/10.1002/fes3.9" @default.
- W2000373300 hasPublicationYear "2012" @default.
- W2000373300 type Work @default.
- W2000373300 sameAs 2000373300 @default.
- W2000373300 citedByCount "11" @default.
- W2000373300 countsByYear W20003733002017 @default.
- W2000373300 countsByYear W20003733002018 @default.
- W2000373300 countsByYear W20003733002020 @default.
- W2000373300 countsByYear W20003733002022 @default.
- W2000373300 countsByYear W20003733002023 @default.
- W2000373300 crossrefType "journal-article" @default.
- W2000373300 hasAuthorship W2000373300A5042669780 @default.
- W2000373300 hasAuthorship W2000373300A5055294011 @default.
- W2000373300 hasBestOaLocation W20003733001 @default.
- W2000373300 hasConcept C134651460 @default.
- W2000373300 hasConcept C181199279 @default.
- W2000373300 hasConcept C185592680 @default.
- W2000373300 hasConcept C2776016237 @default.
- W2000373300 hasConcept C515207424 @default.
- W2000373300 hasConcept C55493867 @default.
- W2000373300 hasConcept C86803240 @default.
- W2000373300 hasConceptScore W2000373300C134651460 @default.
- W2000373300 hasConceptScore W2000373300C181199279 @default.
- W2000373300 hasConceptScore W2000373300C185592680 @default.
- W2000373300 hasConceptScore W2000373300C2776016237 @default.
- W2000373300 hasConceptScore W2000373300C515207424 @default.
- W2000373300 hasConceptScore W2000373300C55493867 @default.
- W2000373300 hasConceptScore W2000373300C86803240 @default.
- W2000373300 hasIssue "2" @default.
- W2000373300 hasLocation W20003733001 @default.
- W2000373300 hasOpenAccess W2000373300 @default.
- W2000373300 hasPrimaryLocation W20003733001 @default.
- W2000373300 hasRelatedWork W1518463994 @default.
- W2000373300 hasRelatedWork W188155302 @default.
- W2000373300 hasRelatedWork W1969170300 @default.
- W2000373300 hasRelatedWork W1987770765 @default.
- W2000373300 hasRelatedWork W1993795649 @default.
- W2000373300 hasRelatedWork W2036649566 @default.
- W2000373300 hasRelatedWork W2081940762 @default.
- W2000373300 hasRelatedWork W2093059412 @default.
- W2000373300 hasRelatedWork W2465575984 @default.
- W2000373300 hasRelatedWork W2511459487 @default.
- W2000373300 hasVolume "1" @default.
- W2000373300 isParatext "false" @default.