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- W2000373331 endingPage "e94632" @default.
- W2000373331 startingPage "e94632" @default.
- W2000373331 abstract "Background Osteosarcoma is the most common primary bone cancer in growing adolescents and young adults. The prognostic role of C-reactive protein (CRP) in patients with osteosarcoma is not fully investigated. The purpose of this study is to perform a meta-analysis and literature review on the role of CRP in osteosarcoma and to assess the potential role of serum CRP as a prognostic factor for patients with osteosarcoma. Methods A detailed literature search was made in Medline for related research publications written in English. Methodological quality of the studies was also evaluated. The data were extracted and assessed by two reviewers independently. Analysis of pooled data were performed, risk ratio (RR) and corresponding confidence intervals (CIs) were calculated and summarized respectively. Results Final analysis of 397 patients from 2 eligible studies was performed. Combined RR of CRP expression suggested that the raised serum CRP level had an adverse prognostic effect on overall survival of patients with osteosarcoma (n = 397 in 2 studies; RR = 0.35; 95% CI: 0.18–0.68; p = 0.002). In the uni- and multivariate survival analysis, response rate and CRP levels were the only independent prognostic variables. Conclusions The results of this meta-analysis suggest that CRP expression confers a worse prognosis in patients with osteosarcoma. Large prospective studies are necessary to provide solid data to confirm the prognostic significance of CRP." @default.
- W2000373331 created "2016-06-24" @default.
- W2000373331 creator A5049328355 @default.
- W2000373331 creator A5050789305 @default.
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- W2000373331 creator A5070144606 @default.
- W2000373331 creator A5072842486 @default.
- W2000373331 creator A5078871565 @default.
- W2000373331 date "2014-05-06" @default.
- W2000373331 modified "2023-10-11" @default.
- W2000373331 title "C-Reactive Protein as a Prognostic Factor for Human Osteosarcoma: A Meta-Analysis and Literature Review" @default.
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